Selenium Level in Patients with Vitiligo: A Meta-Analysis.
Background. It has been reported that deficiency of selenium can cause autoimmune disease. This meta-analysis was aimed at evaluating whether there exits an association between selenium level and vitiligo. Methods. A comprehensive search was conducted on PubMed, Embase, China National Knowledge Infr...
| Published in: | BioMed Research International pp. 1 - 8 |
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| Main Authors: | , , , , , |
| Format: | research systematic review tables/charts Journal Article |
| Published: |
Wiley-Blackwell
6/12/2020
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=143740227&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 143740227 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 6/12/2020 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 143740227 143740227 143740227 10.1155/2020/7580939 143740227 ppf: 1 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Selenium Level in Patients with Vitiligo: A Meta-Analysis. aug: au: Dai, Ting Xiaoying, Sun Li, Xin Hongjin, Li Yaqiong, Zhou Bo, Liang affil: Department of Dermatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China sug: subj: Selenium Blood Vitiligo Diagnosis Human Systematic Review Meta Analysis PubMed Embase Confidence Intervals ab: Background. It has been reported that deficiency of selenium can cause autoimmune disease. This meta-analysis was aimed at evaluating whether there exits an association between selenium level and vitiligo. Methods. A comprehensive search was conducted on PubMed, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Med Online, and China VIP databases from the inception to February 12, 2019. The main outcome was the standardized mean difference (SMD) with 95% confidence interval (CI) in serum selenium level between vitiligo patients and healthy controls. Results. A total of 8 studies with 305 vitiligo patients and 6156 healthy controls were included in this meta-analysis. The results showed that there was no significant difference in selenium level between vitiligo patients and healthy controls (SMD = 0.481 , 95 % CI = − 0.642 to 1.604, Z = 0.840 , P > 0.05). Further subgroup analysis stratified by area revealed that Asian vitiligo patients had decreased selenium level, while that finding was not observed in Caucasian patients (Asian: SMD = − 0.303 , 95 % CI = − 0.603 to −0.004, P < 0.05 ; Caucasian: SMD = 0.957 , 95 % CI = − 0.752 to 2.665, P > 0.05). Conclusions. Although overall selenium level was similar between vitiligo patients and health controls, subgroup analysis showed decreased levels of selenium in Asian vitiligo patients. It may suggest a clinical tailored administration of selenium supplementation in Asian vitiligo patients. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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