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Perinatal biomarkers implying 'Developmental Origins of Health and Disease' consequences in intrauterine growth restriction.

The intrauterine-growth-restricted (IUGR) state, particularly the asymmetric one, has been associated with 'Developmental Origins of Health and Disease' (DOHaD) consequences later in life. Several environmental factors, acting during the phase of foetal developmental plasticity interact with genotyp...

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Published in:Acta Paediatrica Vol. 109; no. 7; pp. 1317 - 1323
Main Authors: Briana, Despina D., Malamitsi‐Puchner, Ariadne, Malamitsi-Puchner, Ariadne
Format: review Journal Article
Published: Wiley-Blackwell Jul2020
Online Access:View this record in EBSCOhost
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        08035253
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      jtl: Acta Paediatrica
      issn: 08035253
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      dt: Jul2020
      vid: 109
      iid: 7
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        143852102
        10.1111/apa.15022
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        143852102
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      formats:
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        atl: Perinatal biomarkers implying 'Developmental Origins of Health and Disease' consequences in intrauterine growth restriction.
      aug:
        au:
          Briana, Despina D.
          Malamitsi‐Puchner, Ariadne
          Malamitsi-Puchner, Ariadne
        affil: Medical School, National and Kapodistrian University of Athens, Athens, Greece
      sug:
        subj:
          DNA Methylation
          Fetal Growth Retardation
          Pregnancy
          Infant, Newborn
          Fetal Blood
          Fetal Development
          Adult
          Female
          Infant, Newborn: birth-1 month
          Adult: 19-44 years
          Female
      ab: The intrauterine-growth-restricted (IUGR) state, particularly the asymmetric one, has been associated with 'Developmental Origins of Health and Disease' (DOHaD) consequences later in life. Several environmental factors, acting during the phase of foetal developmental plasticity interact with genotypic variation, 'programme' tissue function and change the capacity of the organism to cope with its environment. They may be responsible for chronic illness risk in adulthood. Detection of possible future DOHaD consequences at a very early age, by applying relevant biomarkers, is of utmost importance. This review focuses on biomarkers possibly predicting consequences from bone, psychoneural system and lung. Although no concrete biomarker has been identified for bone disorders in adulthood, reduced brain-derived neurotrophic factor (BDNF) concentrations in cord blood and BDNF DNA methylation might predict schizophrenia and possibly depression, bipolar disorder and autism. High surfactant protein D (SP-D) concentrations in cord blood of IUGR foetuses/neonates could point to structural lung immaturity, resulting to asthma and chronic obstructive pulmonary disease in adult life.
      pubtype: Academic Journal
      doctype:
        review
        Journal Article
      ougenre: Article
    language: English
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