Retrograde blood flow in the internal jugular veins of humans with hypertension may have implications for cerebral arterial blood flow.
Objectives: To use multi-parametric magnetic resonance imaging (MRI) to test the hypothesis that hypertensives would have higher retrograde venous blood flow (RVBF) in the internal jugular veins (IJV) vs. normotensives, and that this would inversely correlate with arterial inflow and gray matter, wh...
| Publicado en: | European Radiology Vol. 30; no. 7; pp. 3890 - 3900 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jul2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=143855653&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 143855653 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jul2020 vid: 30 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 143855653 143855653 144100991 NLM32157411 143855653 10.1007/s00330-020-06752-6 NLM32157411 143855653 ppf: 3890 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Retrograde blood flow in the internal jugular veins of humans with hypertension may have implications for cerebral arterial blood flow. aug: au: Rodrigues, Jonathan C. L. Strelko, Galina Warnert, Esther A. H. Burchell, Amy E. Neumann, Sandra Ratcliffe, Laura E. K. Harris, Ashley D. Chant, Benjamin Bowles, Ruth Nightingale, Angus K. Wise, Richard G. Paton, Julian F. R. Hart, Emma C. affil: BHI CardioNomics Research Group, Clinical Research and Imaging Centre-Bristol, School of Physiology, Pharmacology & Neuroscience, University of Bristol, BS8 1TD, Bristol, UK sug: subj: Jugular Veins Jugular Veins Physiopathology Magnetic Resonance Imaging Methods Hypertension Physiopathology Cerebral Arteries Physiopathology Cerebrovascular Circulation Physiology Male Female Free Radicals Prospective Studies Imaging, Three-Dimensional Middle Age Human Middle Aged: 45-64 years Male Female ab: Objectives: To use multi-parametric magnetic resonance imaging (MRI) to test the hypothesis that hypertensives would have higher retrograde venous blood flow (RVBF) in the internal jugular veins (IJV) vs. normotensives, and that this would inversely correlate with arterial inflow and gray matter, white matter, and cerebrospinal fluid volumes.Methods: Following local institutional review board approval and written consent, a prospective observational 3-T MRI study of 42 hypertensive patients (53 ± 2 years, BMI 28.2 ± 0.6 kg/m2, ambulatory daytime systolic BP 148 ± 2 mmHg, ambulatory daytime diastolic BP 101 ± 2 mmHg) and 35 normotensive patients (48 ± 2 years, BMI 25.2 ± 0.8 kg/m2, ambulatory daytime systolic BP 119 ± 3 mmHg, ambulatory daytime diastolic BP 90 ± 2 mmHg) was performed. Phase contrast imaging calculated percentage retrograde venous blood flow (%RVBF), brain segmentation estimated regional brain volumes from 3D T1-weighted images, and pseudo-continuous arterial spin labeling measured regional cerebral blood perfusion. Statistical analysis included two-sample equal variance Student's T tests, two-way analysis of variance with Tukey's post hoc correction, and permutation-based two-group general linear modeling (p < 0.05).Results: In the left IJV, %RVBF was higher in hypertensives (6.1 ± 1.5%) vs. normotensives (1.1 ± 0.3%, p = 0.003). In hypertensives, there was an inverse relationship of %RVBF (permutation-based general linear modeling) to cerebral blood flow in several brain regions, including the left occipital pole and the cerebellar vermis (p < 0.01). Percentage retrograde flow in the left IJV correlated inversely with the total matter volume (gray plus white matter volume) in hypertensives (r = - 0.49, p = 0.004).Conclusion: RVBF in the left IJV is greater in hypertensives vs. normotensives and is linked to regional hypoperfusion and brain total matter volume.Key Points: • Hypertensive humans have higher retrograde cerebral venous blood flow, associated with regional brain hypoperfusion and lower tissue volume, compared with controls. • Cerebral retrograde venous blood flow may add further stress to already hypoperfused tissue in hypertensive patients. • The amount of retrograde venous blood flow in hypertensive patients may predict which patients might be at higher risk of developing cerebral pathologies. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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