Failure of activation of striatum during the performance of executive function tasks in adult patients with bipolar disorder.
Background: Although numerous studies have used functional neuroimaging to identify executive dysfunction in patients with bipolar disorder (BD), the findings are not consistent. The aim of this meta-analysis is to identify the most reliable functional anomalies in BD patients during performance of...
| Publicado en: | Psychological Medicine Vol. 50; no. 4; pp. 653 - 666 |
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| Autores principales: | , , , , , , |
| Formato: | diagnostic images research systematic review tables/charts Journal Article |
| Publicado: |
Cambridge University Press
Mar2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=143895248&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 143895248 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00332917 6Q3 jtl: Psychological Medicine issn: 00332917 maglogo: N pubinfo: dt: Mar2020 vid: 50 iid: 4 pid: 15979 pub: Cambridge University Press artinfo: ui: 143895248 143895248 143895248 10.1017/S0033291719000473 143895248 ppf: 653 ppct: 13 formats: tig: atl: Failure of activation of striatum during the performance of executive function tasks in adult patients with bipolar disorder. aug: au: Tian, Fangfang Diao, Wei Yang, Xun Wang, Xiuli Roberts, Neil Feng, Can Jia, Zhiyun affil: Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, China sug: subj: Task Performance and Analysis Executive Function Evaluation Basal Ganglia Physiopathology Bipolar Disorder Physiopathology Bipolar Disorder Psychosocial Factors Psychiatric Patients Psychosocial Factors Human Meta Analysis Systematic Review Adult Effect Size Magnetic Resonance Imaging Bipolar Disorder Diagnosis Frontal Lobe Physiopathology Cerebellum Physiopathology Temporal Lobe Physiopathology Sensitivity and Specificity PubMed Embase Adult: 19-44 years ab: Background: Although numerous studies have used functional neuroimaging to identify executive dysfunction in patients with bipolar disorder (BD), the findings are not consistent. The aim of this meta-analysis is to identify the most reliable functional anomalies in BD patients during performance of Executive Function (EF) tasks. Methods: A web-based search was performed on publication databases to identify functional magnetic resonance imaging studies of BD patients performing EF tasks and a voxel-based meta-analytic method known as anisotropic Effect Size Signed Differential Mapping (ES-SDM) was used to identify brain regions which showed anomalous activity in BD patients compared with healthy controls (HC). Results: Twenty datasets consisting of 463 BD patients and 484 HC were included. Compared with HC, BD patients showed significant hypo-activation or failure of activation in the left striatum (p = 0.00007), supplementary motor area (BA 6, p = 0.00037), precentral gyrus (BA 6, p = 0.0014) and cerebellum (BA 37, p = 0.0019), and hyper-activation in the left gyrus rectus (BA 11, p ≈ 0) and right middle temporal gyrus (BA 22, p = 0.00031) during performance of EF tasks. Sensitivity and subgroup analyses showed that the anomaly of left striatum is consistent across studies and present in both euthymic and BD I patients. Conclusions: Patients with BD consistently showed abnormal activation in the cortico-striatal system during performance of EF tasks compared with HC. Failure of activation of the striatum may be a reliable marker for impairment in performance of especially inhibition tasks by patients with BD. pubtype: Academic Journal doctype: diagnostic images meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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