Born with a solitary kidney: at risk of hypertension.
Background: Subjects with a congenital solitary kidney (CSK) are believed to be at risk of hypertension due to their low number of nephrons. However, as CSK is a congenital abnormality of the kidney or urinary tract (CAKUT), subtle dysplastic changes contributing to hypertension cannot be excluded....
| Publicado en: | Pediatric Nephrology Vol. 35; no. 8; pp. 1483 - 1491 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=144237395&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 144237395 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Aug2020 vid: 35 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 144237395 144170729 144237395 144237395 10.1007/s00467-020-04535-1 144237395 ppf: 1483 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Born with a solitary kidney: at risk of hypertension. aug: au: La Scola, Claudio Marra, Giuseppina Ammenti, Anita Pasini, Andrea Taroni, Francesca Bertulli, Cristina Morello, William Ceccoli, Martina Mencarelli, Francesca Guarino, Stefano Puccio, Giuseppe Montini, Giovanni affil: Nephrology and Dialysis Unit, Department of Pediatrics, Azienda Ospedaliero Universitaria Sant'Orsola-Malpighi, Bologna, Italy sug: subj: Abnormalities Complications Solitary Kidney Complications Hypertension Risk Factors Risk Assessment Human Male Female Child Adolescence Retrospective Design Blood Pressure Monitoring, Ambulatory Descriptive Statistics Data Analysis Software Chi Square Test Wilcoxon Rank Sum Test Kruskal-Wallis Test Fisher's Exact Test Child: 6-12 years Adolescent: 13-18 years Male Female ab: Background: Subjects with a congenital solitary kidney (CSK) are believed to be at risk of hypertension due to their low number of nephrons. However, as CSK is a congenital abnormality of the kidney or urinary tract (CAKUT), subtle dysplastic changes contributing to hypertension cannot be excluded. Methods: We retrospectively compared office blood pressure (OBP) and ambulatory blood pressure monitoring (ABPM) between two groups of children with CAKUT, aged 6–18 years: Group A with a CSK and Group B with two kidneys. All had normal renal parenchyma on scintigraphy and normal renal function. OBP and mean systolic and diastolic 24-h, daytime and nighttime ambulatory BP records were analyzed. The distribution of OBP and APBM as continuous values and the prevalence of hypertension (ambulatory/severe ambulatory or masked hypertension) in the two groups were compared. Results: There were 81 patients in Group A and 45 in Group B. Median OBP standard deviation scores were normal in both groups, without significant differences. Median ABPM standard deviation scores, although normal, were significantly higher in Group A and the prevalence of hypertension was higher (ambulatory/severe ambulatory or masked) (33.3 vs. 13.3%, p = 0.019), mainly because of the greater occurrence of masked hypertension. Conclusions: Our data show that a CSK per se can be associated with an increased risk of hypertension from the pediatric age. Therefore, ABPM, which has proved valuable in the screening of hypertension, is warranted in children with a CSK, even if laboratory and imaging assessment is otherwise normal. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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