Distortion product otoacoustic emission sensitivity to different solvents in a population of industrial painters.
Objective: To evaluate the ototoxic effect of the exposure to different organic solvents and noise using distortion product otoacoustic emissions (DPOAEs). Design: The exposure to different solvents was evaluated by measuring, before and at the end of the work-shift, the urinary concentrations of so...
| Publicado en: | International Journal of Audiology Vol. 59; no. 6; pp. 443 - 455 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Jun2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=144260995&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 144260995 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14992027 JW2 jtl: International Journal of Audiology issn: 14992027 maglogo: Y pubinfo: dt: Jun2020 vid: 59 iid: 6 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 144260995 144260995 144260995 10.1080/14992027.2019.1710776 144260995 ppf: 443 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Distortion product otoacoustic emission sensitivity to different solvents in a population of industrial painters. aug: au: Sisto, Renata Cerini, Luigi Sanjust, Filippo Carbonari, Damiano Gherardi, Monica Gordiani, Andrea L'Episcopo, Nunziata Paci, Enrico Pigini, Daniela Tranfo, Giovanna Moleti, Arturo affil: Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, INAIL Research, Monteporzio Catone, Italy sug: subj: Otoacoustic Emissions, Evoked Solvents Adverse Effects Ototoxicity Diagnosis Occupational Exposure Adverse Effects Noise Adverse Effects Organic Chemicals Adverse Effects Inhalation Exposure Adverse Effects Paint Industry Human Adult Middle Age Funding Source Metabolites Biological Markers Urine Oxidative Stress Audiometry, Pure-Tone Multiple Linear Regression Descriptive Statistics Confidence Intervals Questionnaires Age Factors T-Tests Comparative Studies Chi Square Test Analysis of Variance Ships Adult: 19-44 years Middle Aged: 45-64 years ab: Objective: To evaluate the ototoxic effect of the exposure to different organic solvents and noise using distortion product otoacoustic emissions (DPOAEs). Design: The exposure to different solvents was evaluated by measuring, before and at the end of the work-shift, the urinary concentrations of solvent metabolites used as dose biomarkers. The urinary concentrations of DNA and RNA oxidation products were also measured as biomarkers of oxidative damage. The simultaneous exposure to noise was also evaluated. DPOAEs and pure tone audiometry (PTA) were used as outcome variables, and were correlated to the exposure variables using mixed effect linear regression models. Study sample: Seventeen industrial painters exposed to a solvent mixture in a naval industry. A sample size of 15 was estimated from previous studies as sufficient for discriminating small hearing level and DPOAE level differences (5 dB and 2 dB, respectively) at a 95% confidence level. Results: Statistically significant associations were found between the DPOAE level and the urinary dose biomarkers and the oxidative damage biomarkers. DPOAE level and the logarithm of the metabolite concentration showed a significant negative correlation. Conclusions: DPOAE are sensitive biomarkers of exposure to ototoxic substances and can be effectively used for the early detection of hearing dysfunction. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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