Contribution to understand the biomineralization of bones.
Introduction: The goal is to propose a material scientific hypothesis for the atomic arrangement of calcium phosphates during the mineralization of bones.Materials and Methods: It was reached by the analysis of bones of healthy and osteoporotic rats using analytical transmission electron microscopic...
| Publicado en: | Journal of Bone & Mineral Metabolism Vol. 38; no. 4; pp. 456 - 469 |
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| Autores principales: | , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jul2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=144282359&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 144282359 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09148779 NR4 jtl: Journal of Bone & Mineral Metabolism issn: 09148779 maglogo: N pubinfo: dt: Jul2020 vid: 38 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 144282359 143919402 144282359 NLM32008099 10.1007/s00774-020-01083-4 NLM32008099 144282359 ppf: 456 ppct: 13 formats: tig: atl: Contribution to understand the biomineralization of bones. aug: au: Thomas, Jürgen Worch, Hartmut Kruppke, Benjamin Gemming, Thomas affil: Leibniz Institute for Solid State and Materials Research Dresden, Helmholtzstraße 20, 01069, Dresden, Germany sug: subj: Bone and Bones Physiology X-Rays Phosphates Female Minerals Rats Animals Bone and Bones Female ab: Introduction: The goal is to propose a material scientific hypothesis for the atomic arrangement of calcium phosphates during the mineralization of bones.Materials and Methods: It was reached by the analysis of bones of healthy and osteoporotic rats using analytical transmission electron microscopic methods.Results: Electron diffraction patterns show hydroxyapatite (HAP) as dominant phase within the mineralized areas. In the electron energy loss spectrum, a double peak of the phosphorous L-edge seems to be a characteristic feature of the phosphorous binding in biological HAP. The hypothesis bases on periodic features on the collagen surface which agree with distances between oxygen atoms in the (200) plane of octacalcium phosphate (OCP). Bridge pillars for the HAP network consist of OCP coupled with a half unit cell on collagen by oxygen-hydrogen bridges. Possibly, the metastable OCP bridges are only a transient step, while the mineralization is starting. OCP and HAP couple by similar distances of calcium atoms in an interface close to the (100) planes of the OCP and the HAP network. To reach the perfect overlap of the equidistant Ca atoms, the HAP network has to be rotated by 22.5° around the a-axis, 11.5° around the c-axis of HAP, and 10.1° around an axis perpendicular to a and c.Conclusions: A supercell based on this idea is able to explain the dominance of HAP in the electron diffraction patterns, the arrangement of the (002) lattice planes perpendicular to the collagen fiber axis, and sections of high-resolution TEM images. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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