Randomized cross-over trial of demand oxygen delivery system in nocturnal hypoxemia.
Background: It has not been determined that demand valve oxygen therapy is effective for nocturnal hypoxia. A portable oxygen concentrator with an auto-demand oxygen delivery system (auto-DODS; standard, high, and extra high) has recently been developed to improve oxygenation and comfort. This oxyge...
| Publicado en: | Medicine Vol. 99; no. 19; pp. 1 - 5 |
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| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
5/1/2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=144310126&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 144310126 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00257974 2S6 jtl: Medicine issn: 00257974 maglogo: N pubinfo: dt: 5/1/2020 vid: 99 iid: 19 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 144310126 144310126 NLM32384462 144310126 10.1097/MD.0000000000020031 NLM32384462 144310126 ppf: 1 ppct: 4 formats: tig: atl: Randomized cross-over trial of demand oxygen delivery system in nocturnal hypoxemia. aug: au: Tatsuya Nagano Kazuyuki Kobayashi Takashi Omori Takehiro Otoshi Kanoko Umezawa Naoko Katsurada Masatsugu Yamamoto Motoko Tachihara Yoshihiro Nishimura Nagano, Tatsuya Kobayashi, Kazuyuki Omori, Takashi Otoshi, Takehiro Umezawa, Kanoko Katsurada, Naoko Yamamoto, Masatsugu Tachihara, Motoko Nishimura, Yoshihiro affil: Clinical and Translational Research Center, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, Japan sug: subj: Oxygen Therapy Equipment and Supplies Nebulizers and Vaporizers Lung Diseases, Interstitial Complications Pulmonary Disease, Chronic Obstructive Complications Oxygen Therapy Methods Reproducibility of Results Adult Recovery Oximetry Methods Crossover Design Female Polysomnography Methods Human Male Randomized Controlled Trials Adult: 19-44 years Female Male ab: Background: It has not been determined that demand valve oxygen therapy is effective for nocturnal hypoxia. A portable oxygen concentrator with an auto-demand oxygen delivery system (auto-DODS; standard, high, and extra high) has recently been developed to improve oxygenation and comfort. This oxygen concentrator can supply a pulsed flow when it detects apnoea. The aim of this study is to demonstrate that this newly developed portable oxygen concentrator with an auto-demand function is non-inferior to a continuous-flow oxygen concentrator for nocturnal hypoxemia.Methods: Twenty patients with chronic obstructive pulmonary disease or interstitial pneumonia will be randomized to receive a portable oxygen concentrator with an auto-DODS or a continuous-flow oxygen concentrator during sleep. The primary endpoint is mean oxygen saturation (SpO2) during the total sleep time. The secondary endpoints are the ratios of time that the oxygen concentrator spends in each sensitivity mode (standard, high, and extra-high) and at a constant pulse rate to the total sleep time, the total time and ratio of time for which SpO2 is less than 90% during the total sleep time, the lowest value of SpO2 during the total sleep time, the mean and highest pulse rate during the total sleep time, the apnoea index during the total sleep time, the total sleep duration itself, and comfort and reliability as measured by numerical rating scale and questionnaires.Discussion: If the auto-DODS demonstrates non-inferiority to continuous flow in oxygenation during sleep, the auto-DODS can be used even at night, and the patient will need only 1 device.Trial Registration: The study was registered on Aug 23, 2019 (jRCTs052190042). pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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