Individualized and inverse optimized needle configuration for combined intracavitary-interstitial brachytherapy in locally advanced cervical cancer.
Objectives: The aim of this study is to address the limitation of combined intracavitary-interstitial (IC/IS) brachytherapy (BT) in locally advanced cervical cancer using standardized applicators and to determine the optimal dose distribution in patients with challenging tumors, innovative methods o...
| Publicado en: | Journal of Cancer Research & Therapeutics Vol. 15; no. 7; pp. 1589 - 1597 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wolters Kluwer India Pvt Ltd
2019
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=144329245&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 144329245 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09731482 1BS3 jtl: Journal of Cancer Research & Therapeutics issn: 09731482 maglogo: N pubinfo: dt: 2019 vid: 15 iid: 7 pid: 16919 pub: Wolters Kluwer India Pvt Ltd artinfo: ui: 144329245 144329245 NLM31939442 144329245 10.4103/jcrt.JCRT_292_19 NLM31939442 144329245 ppf: 1589 ppct: 8 formats: tig: atl: Individualized and inverse optimized needle configuration for combined intracavitary-interstitial brachytherapy in locally advanced cervical cancer. aug: au: Zhang, Daguang Yang, Zhiyong Jiang, Shan Zhou, Lin Zhou, Zeyang Wang, Wei affil: School of Mechanical Engineering, Tianjin University, Tianjin, China sug: subj: Cervix Neoplasms Radiotherapy Cervix Neoplasms Diagnosis Brachytherapy Methods Radiotherapy, Computer-Assisted Methods Neoplasm Staging Radiation Dosage Magnetic Resonance Imaging Radiotherapy Dose-Response Relationship, Radiation Female Human Female ab: Objectives: The aim of this study is to address the limitation of combined intracavitary-interstitial (IC/IS) brachytherapy (BT) in locally advanced cervical cancer using standardized applicators and to determine the optimal dose distribution in patients with challenging tumors, innovative methods of customizing and optimizing the IS needle configuration for combined IC/IS BT are proposed and investigated.Materials and Methods: A software module that could customize the IS needle configuration and subsequently generate the digital model of guiding template for three-dimensional printing was developed and integrated into our in-house treatment planning system for BT. The inverse optimization method based on the technique of mixed-integer linear programming was introduced to determine the needle tracks out of a candidate pool and dwell times at corresponding locations to best meet dose objectives. A treatment planning study was conducted to evaluate the feasibility and performance of the proposed methods.Results: The workflow for combined IC/IS BT with customized and inverse optimized IS needle configuration was presented. Dosimetric results of the treatment planning study showed that sufficient target coverage could be obtained with the customized IS needle configuration for challenging cases. The proposed dose-based optimization method for IS needle configuration was feasible and effective. Improved target coverage and organ-at-risk sparing were achieved using the inverse planning method.Conclusions: Using the proposed methods of customizing and optimizing the IS needle configuration, the limitation in the standardized design of combined IC/IS applicators can be addressed, and sufficient target coverage is obtained in cervical cancer patients with unfavorable tumor topography and/or extra lateral expansion. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|