Stratification of Individual Symptoms of Contact Lens-Associated Dry Eye Using the iPhone App DryEyeRhythm: Crowdsourced Cross-Sectional Study.
Background: Discontinuation of contact lens use is mainly caused by contact lens-associated dry eye. It is crucial to delineate contact lens-associated dry eye's multifaceted nature to tailor treatment to each patient's individual needs for future personalized medicine.Objective: This paper aims to...
| Published in: | Journal of Medical Internet Research Vol. 22; no. 6 |
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| Main Authors: | , , , , , , , , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
JMIR Publications Inc.
Jun2020
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=144387091&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 144387091 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14394456 DNC jtl: Journal of Medical Internet Research issn: 14394456 maglogo: N pubinfo: dt: Jun2020 vid: 22 iid: 6 pid: 21567 pub: JMIR Publications Inc. place: Toronto, Ontario artinfo: ui: 144387091 144387091 NLM32589162 144387091 10.2196/18996 NLM32589162 144387091 ppct: 1 formats: tig: atl: Stratification of Individual Symptoms of Contact Lens-Associated Dry Eye Using the iPhone App DryEyeRhythm: Crowdsourced Cross-Sectional Study. aug: au: Inomata, Takenori Nakamura, Masahiro Iwagami, Masao Midorikawa-Inomata, Akie Sung, Jaemyoung Fujimoto, Keiichi Okumura, Yuichi Eguchi, Atsuko Iwata, Nanami Miura, Maria Fujio, Kenta Nagino, Ken Hori, Satoshi Tsubota, Kazuo Dana, Reza Murakami, Akira affil: Department of Ophthalmology, Juntendo University Faculty of Medicine, Tokyo, Japan sug: subj: Dry Eye Syndromes Complications Mobile Applications Standards Crowdsourcing Methods Contact Lenses Adverse Effects Prospective Studies Adult Human Cross Sectional Studies Incidence Risk Factors Female Male Validation Studies Comparative Studies Evaluation Research Multicenter Studies Adult: 19-44 years Female Male ab: Background: Discontinuation of contact lens use is mainly caused by contact lens-associated dry eye. It is crucial to delineate contact lens-associated dry eye's multifaceted nature to tailor treatment to each patient's individual needs for future personalized medicine.Objective: This paper aims to quantify and stratify individual subjective symptoms of contact lens-associated dry eye and clarify its risk factors for future personalized medicine using the smartphone app DryEyeRhythm (Juntendo University).Methods: This cross-sectional study included iPhone (Apple Inc) users in Japan who downloaded DryEyeRhythm. DryEyeRhythm was used to collect medical big data related to contact lens-associated dry eye between November 2016 and January 2018. The main outcome measure was the incidence of contact lens-associated dry eye. Univariate and multivariate adjusted odds ratios of risk factors for contact lens-associated dry eye were determined by logistic regression analyses. The t-distributed Stochastic Neighbor Embedding algorithm was used to depict the stratification of subjective symptoms of contact lens-associated dry eye.Results: The records of 4454 individuals (median age 27.9 years, SD 12.6), including 2972 female participants (66.73%), who completed all surveys were included in this study. Among the included participants, 1844 (41.40%) were using contact lenses, and among those who used contact lenses, 1447 (78.47%) had contact lens-associated dry eye. Multivariate adjusted odds ratios of risk factors for contact lens-associated dry eye were as follows: younger age, 0.98 (95% CI 0.96-0.99); female sex, 1.53 (95% CI 1.05-2.24); hay fever, 1.38 (95% CI 1.10-1.74); mental illness other than depression or schizophrenia, 2.51 (95% CI 1.13-5.57); past diagnosis of dry eye, 2.21 (95% CI 1.63-2.99); extended screen exposure time >8 hours, 1.61 (95% CI 1.13-2.28); and smoking, 2.07 (95% CI 1.49-2.88). The t-distributed Stochastic Neighbor Embedding analysis visualized and stratified 14 groups based on the subjective symptoms of contact lens-associated dry eye.Conclusions: This study identified and stratified individuals with contact lens-associated dry eye and its risk factors. Data on subjective symptoms of contact lens-associated dry eye could be used for prospective prevention of contact lens-associated dry eye progression. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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