Liver stiffness measured by MR elastography is a predictor of early HCC recurrence after treatment.
Objectives: Magnetic resonance elastography (MRE) is a non-invasive tool for measuring liver stiffness (LS) with high diagnostic accuracy. This study investigated whether quantified LS by MRE could predict early recurrence of patients with hepatocellular carcinoma (HCC) within the Milan criteria.Met...
| Publicado en: | European Radiology Vol. 30; no. 8; pp. 4182 - 4193 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Aug2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=144404686&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 144404686 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Aug2020 vid: 30 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 144404686 143970032 144404686 NLM32189053 10.1007/s00330-020-06792-y NLM32189053 144404686 ppf: 4182 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Liver stiffness measured by MR elastography is a predictor of early HCC recurrence after treatment. aug: au: Cho, Hyo Jung Kim, Bohyun Kim, Hye Jin Huh, Jimi Kim, Jai Keun Lee, Jei Hee Seo, Chul Won Ahn, Hye Ri Eun, Jung Woo Kim, Soon Sun Cho, Sung Won Cheong, Jae Youn affil: Department of Gastroenterology, Ajou University School of Medicine, Worldcup-ro 164, Yeongtong-Gu, 443-380, Suwon, South Korea sug: subj: Ultrasonography Neoplasm Recurrence, Local Liver Neoplasms Carcinoma, Hepatocellular Liver Neoplasms Surgery Liver Neoplasms Pathology Adult Male Kaplan-Meier Estimator Chemoembolization, Therapeutic Adverse Effects Treatment Outcomes Carcinoma, Hepatocellular Pathology Hepatectomy Middle Age Aged Aged, 80 and Over Carcinoma, Hepatocellular Surgery Risk Factors Catheter Ablation Female Retrospective Design Cox Proportional Hazards Model Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Objectives: Magnetic resonance elastography (MRE) is a non-invasive tool for measuring liver stiffness (LS) with high diagnostic accuracy. This study investigated whether quantified LS by MRE could predict early recurrence of patients with hepatocellular carcinoma (HCC) within the Milan criteria.Methods: A prospectively collected cohort, which included the HCC patients who underwent MRE before treatment (an HCC-MRE cohort), was analyzed. In the HCC-MRE cohort, only patients under the Milan criteria, who underwent hepatic resection, radiofrequency ablation (RFA), or transarterial chemoembolization (TACE), were reviewed. We investigated whether LS assessed by MRE was an independent predictor of early recurrence using Cox regressions and Kaplan-Meier analyses.Results: A total of 192 HCC patients under the Milan criteria who underwent hepatic resection (n = 96), RFA (n = 23), or TACE (n = 73) were included. Higher LS ratings (kPa; hazard ratio [HR] = 1.12; 95% confidence interval [CI] = 1.01-1.25; p = 0.040) emerged as an independent risk factor for early tumor recurrence. In the subgroup analysis, higher LS ratings were associated with higher risks of early HCC recurrence in both the resection/RFA group (> 4.5 kPa; HR = 2.95; 95% CI = 1.26-6.94; p = 0.013) and the TACE group (> 6 kPa; HR = 2.94; 95% CI = 1.27-6.83; p = 0.012).Conclusion: LS assessed by MRE was an independent predictor of early recurrence among HCC patients under the Milan criteria after achieving a complete response.Key Points: • Liver parenchymal stiffness measured by MRE predicts early recurrence of treated HCC under Milan criteria. • A liver stiffness > 5.5 kPa was associated with worse recurrence-free survival. • Patients with high pre-treatment LS may benefit from stringent follow-up. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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