Comparison of vortioxetine and sertraline for treatment of major depressive disorder in elderly patients: A double‐blind randomized trial.
What is known and objective: Major depressive disorder (MDD) is a complex disease and one of the leading contributors to disease burden throughout the world. In the current study, we explored the efficacy and tolerability of vortioxetine versus sertraline on symptoms of depression in elderly patient...
| Publicado en: | Journal of Clinical Pharmacy & Therapeutics Vol. 45; no. 4; pp. 804 - 812 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Wiley-Blackwell
Aug2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=144405618&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 144405618 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: Aug2020 vid: 45 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 144405618 144405618 144405618 10.1111/jcpt.13177 144405618 ppf: 804 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Comparison of vortioxetine and sertraline for treatment of major depressive disorder in elderly patients: A double‐blind randomized trial. aug: au: Borhannejad, Firouzeh Shariati, Behnam Naderi, Sina Shalbafan, Mohammadreza Mortezaei, Amirhosein Sahebolzamani, Erfan Saeb, Atefe Hosein Mortazavi, Seyyed Kamalzadeh, Leila Aqamolaei, Ali Ali Noorbala, Ahmad Namazi‐Shabestari, Alireza Akhondzadeh, Shahin affil: Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran sug: subj: Depression Drug Therapy Depression Symptoms Piperidines Therapeutic Use Sertraline Hydrochloride Therapeutic Use Antidepressive Agents Therapeutic Use Treatment Outcomes Human Randomized Controlled Trials Random Assignment Double-Blind Studies Piperidines Administration and Dosage Sertraline Hydrochloride Administration and Dosage Comparative Studies Repeated Measures Patient Safety Hamilton Rating Scale for Depression Psychological Tests Aged Aged: 65+ years ab: What is known and objective: Major depressive disorder (MDD) is a complex disease and one of the leading contributors to disease burden throughout the world. In the current study, we explored the efficacy and tolerability of vortioxetine versus sertraline on symptoms of depression in elderly patients with MDD. Methods: Sixty patients diagnosed with MDD (based on DSM‐5) and Hamilton Depression Rating Scale (HAM‐D) score ≥ 19 were entered into a randomized double‐blind study and were randomized to receive either vortioxetine (15 mg daily) or sertraline (75 mg daily) for six weeks. Patients were assessed using the HAM‐D scale at baseline and weeks 3 and 6. Changes in HAM‐D score, response rates, remission rate and time to response or remission were also compared between the two study groups. Results and Discussion: Fifty patients completed the trial after six weeks. General linear model repeated measures demonstrated no difference in trend of the two treatment groups (P =.897). There was no significantly different improvement in the HDRS scores from baseline to weeks 3 and 6, as well. Differences in response rate, remission rate, time to response and time to remission periods were not statistically significant. Finally, there was not any significantly difference between the two study groups in the frequency of adverse events. What is new and conclusion: This study showed no significant differences in the efficacy and safety of vortioxetine in comparison with sertraline in order for it to be used safely for treatment of major depressive disorder in elderly patients. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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