Additive effect of erythropoietin use on exercise-induced endothelial activation and hypercoagulability in athletes.
Purpose: Recombinant human erythropoietin (rHuEPO) is known to increase thrombotic risk in patients and might have similar effects in athletes abusing the drug. rHuEPO is prohibited by anti-doping legislation, but this risk has not been investigated thoroughly. This analysis was designed to evaluate...
| Publicado en: | European Journal of Applied Physiology Vol. 120; no. 8; pp. 1893 - 1905 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Aug2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=144423649&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 144423649 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14396319 NP8 jtl: European Journal of Applied Physiology issn: 14396319 maglogo: N pubinfo: dt: Aug2020 vid: 120 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 144423649 144043484 144423649 NLM32537688 144423649 10.1007/s00421-020-04419-0 NLM32537688 144423649 ppf: 1893 ppct: 12 formats: tig: atl: Additive effect of erythropoietin use on exercise-induced endothelial activation and hypercoagulability in athletes. aug: au: Heuberger, Jules A. A. C. Posthuma, Jelle J. Ziagkos, Dimitrios Rotmans, Joris I. Daniels, Johannes M. A. Gal, Pim Stuurman, Frederik E. Spronk, Henri M. H. Ten Cate, Hugo Burggraaf, Jacobus Moerland, Matthijs Cohen, Adam F. affil: Centre for Human Drug Research, Zernikedreef 8, 2333 CL, Leiden, The Netherlands sug: subj: Exercise Blood Coagulation Drug Effects Erythropoietin Pharmacodynamics Endothelium Drug Effects Proteins Metabolism Endothelium Metabolism Athletes Erythropoietin Adverse Effects Male Middle Age Adult Platelet Activation Drug Effects Comparative Studies Multicenter Studies Randomized Controlled Trials Evaluation Research Validation Studies Human Middle Aged: 45-64 years Adult: 19-44 years Male ab: Purpose: Recombinant human erythropoietin (rHuEPO) is known to increase thrombotic risk in patients and might have similar effects in athletes abusing the drug. rHuEPO is prohibited by anti-doping legislation, but this risk has not been investigated thoroughly. This analysis was designed to evaluate whether rHuEPO impacts hemostatic profile and endothelial and platelet activation markers in trained subjects, and whether the combination with exercise affects exercise induced alterations.Methods: This double-blind, randomized, placebo-controlled trial enrolled healthy, trained male cyclists aged 18-50 years. Participants were randomly allocated (1:1) to receive subcutaneous injections of rHuEPO (epoetin-β; mean dose 6000 IU per week) or placebo (0.9% NaCl) for 8 weeks. Subjects performed five maximal exercise tests and a road race, coagulation and endothelial/platelet markers were measured at rest and directly after each exercise effort.Results: rHuEPO increased P-selectin (+ 7.8% (1.5-14.5), p = 0.02) and E-selectin (+ 8.6% (2.0-15.7), p = 0.01) levels at rest. Maximal exercise tests significantly influenced all measured coagulation and endothelial/platelet markers, and in the rHuEPO group maximal exercise tests led to 15.3% ((7.0-24.3%), p = 0.0004) higher E-selectin and 32.1% ((4.6-66.8%), p = 0.0207) higher Platelet factor 4 (PF4) levels compared to the placebo group.Conclusion: In conclusion, rHuEPO treatment resulted in elevated E- and P-selectin levels in trained cyclists, indicating enhanced endothelial activation and/or platelet reactivity. Exercise itself induces hypercoagulability, and the combination of rHuEPO and exercise increased E-selectin and PF4 levels more than either intervention alone. Based on this, exercise potentially increases thrombotic risk, a risk that might be enhanced in combination with rHuEPO use. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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