Macrophages use a bet-hedging strategy for antimicrobial activity in phagolysosomal acidification.
Microbial ingestion by a macrophage results in the formation of an acidic phagolysosome but the host cell has no information on the pH susceptibility of the ingested organism. This poses a problem for the macrophage and raises the fundamental question of how the phagocytic cell optimizes the acidifi...
| Publicado en: | Journal of Clinical Investigation Vol. 130; no. 7; pp. 3805 - 3820 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
American Society for Clinical Investigation
Jul2020
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| Acceso en línea: | Ver este registro en EBSCOhost |