Dormancy in Cryptococcus neoformans: 60 years of accumulating evidence.
Cryptococcus neoformans is an opportunistic yeast that is present worldwide and interacts with various organisms. In humans, it is responsible for cryptococcosis, a deadly invasive fungal infection that represents around 220,000 cases per year worldwide. Starting from the natural history of the dise...
| Publicado en: | Journal of Clinical Investigation Vol. 130; no. 7; pp. 3353 - 3361 |
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| Autor principal: | |
| Formato: | review Journal Article |
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American Society for Clinical Investigation
Jul2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=144488493&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 144488493 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00219738 0YX jtl: Journal of Clinical Investigation issn: 00219738 maglogo: N pubinfo: dt: Jul2020 vid: 130 iid: 7 pid: 11983 pub: American Society for Clinical Investigation place: Ann Arbor, Michigan artinfo: ui: 144488493 144488493 NLM32484459 144488493 10.1172/JCI136223 NLM32484459 144488493 ppf: 3353 ppct: 8 formats: tig: atl: Dormancy in Cryptococcus neoformans: 60 years of accumulating evidence. aug: au: Alanio, Alexandre affil: Laboratoire de Parasitologie-Mycologie, Groupe Hospitalier Saint-Louis-Lariboisière-Fernand-Widal, Assistance Publique–Hôpitaux de Paris (AP-HP), Paris, France. sug: subj: Cryptococcus Metabolism Cryptococcus Cryptococcosis Metabolism Adaptation, Physiological Virulence Animals ab: Cryptococcus neoformans is an opportunistic yeast that is present worldwide and interacts with various organisms. In humans, it is responsible for cryptococcosis, a deadly invasive fungal infection that represents around 220,000 cases per year worldwide. Starting from the natural history of the disease in humans, there is accumulating evidence on the capacity of this organism to enter dormancy. In response to the harsh host environment, the yeast is able to adapt dramatically and escape the vigilance of the host's immune cells to survive. Indeed, the yeast exposed to the host takes on pleiotropic phenotypes, enabling the generation of populations in heterogeneous states, including dormancy, to eventually survive at low metabolic cost and revive in favorable conditions. The concept of dormancy has been validated in C. neoformans from both epidemiological and genotyping data, and more recently from the biological point of view with the characterization of dormancy through the description of viable but nonculturable cells. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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