Pre-meal protein intake alters postprandial plasma metabolome in subjects with metabolic syndrome.
Purpose: We examined the effect on the postprandial plasma metabolome of protein pre-meals before a fat-rich main meal. Methods: Two randomized, cross-over meal studies were conducted to test the dose–response effect (0 g, 10 g, 20 g) of a pre-meal with whey protein (WP) (PREMEAL I), and the effect...
| Publicado en: | European Journal of Nutrition Vol. 59; no. 5; pp. 1881 - 1895 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Aug2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=144498639&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 144498639 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Aug2020 vid: 59 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 144498639 144019179 144498639 144498639 10.1007/s00394-019-02039-9 144498639 ppf: 1881 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Pre-meal protein intake alters postprandial plasma metabolome in subjects with metabolic syndrome. aug: au: Pekmez, Ceyda Tugba Bjørnshave, Ann Pratico, Giulia Hermansen, Kjeld Dragsted, Lars Ove affil: Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958, Frederiksberg C, Denmark sug: subj: Postprandial Period Metabolomics Metabolic Syndrome X Food Intake Proteins Meals Randomized Controlled Trials Crossover Design Diet, Atherogenic Chromatography, Liquid Mass Spectrometry Gluten Caseins Amino Acids, Branched-Chain Whey Proteins Breakfast Metabolites Insulin Resistance Biological Markers Human ab: Purpose: We examined the effect on the postprandial plasma metabolome of protein pre-meals before a fat-rich main meal. Methods: Two randomized, cross-over meal studies were conducted to test the dose–response effect (0 g, 10 g, 20 g) of a pre-meal with whey protein (WP) (PREMEAL I), and the effect of protein quality (10 g WP, casein, or gluten) and timing (− 15 min vs − 30 min) of the pre-meal (PREMEAL II). Participants with metabolic syndrome received one of the test meals on each test day, − 15 min (or − 30 min) prior to a standardized fat-rich breakfast. Plasma samples were collected at − 15 min (or − 30 min), 0, 120, 240 a nd 360 min and analyzed using liquid chromatography–mass spectrometry with an untargeted method. Results: Pre-meal WP intake elevated plasma branched-chain amino acids (BCAA), aromatic amino acids and methionine and decreased plasma LPC (16:0) and PC (32:1) levels before the main meal. Early (− 15 to 0 min) aromatic amino acids and BCAA in response to pre-meal WP partially predict the glucose and insulin response after the main meal. A pre-meal with WP altered the postprandial plasma metabolic pattern of acyl-carnitines, specific PCs, LPCs and LPEs, betaine, citric acid, linoleic acid, and β-hydroxypalmitic acid compared to no pre-meal. The casein and WP pre-meals exhibited similar postprandial amino acid responses whereas a pre-meal with gluten resulted in lower levels of plasma amino acids and its metabolites. Conclusion: A pre-meal with protein affects the postprandial metabolic pattern indicating facilitated glucose and lipid disposal from plasma in participants with metabolic syndrome. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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