Resting-state fMRI analysis in apathetic Alzheimer's disease.
Purpose: Diagnosis of comorbid psychiatric conditions are a significant determinant for the prognosis of neurodegenerative diseases. Apathy, which is a behavioral executive dysfunction, frequently accompanies Alzheimer's disease (AD) and leads to higher daily functional loss. We assume that frontal...
| Publicado en: | Diagnostic & Interventional Radiology Vol. 26; no. 4; pp. 363 - 370 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Galenos Yayinevi Tic. LTD. STI
Jul2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=144512751&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 144512751 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13053825 39NM jtl: Diagnostic & Interventional Radiology issn: 13053825 maglogo: N pubinfo: dt: Jul2020 vid: 26 iid: 4 pid: 28155 pub: Galenos Yayinevi Tic. LTD. STI artinfo: ui: 144512751 144512751 NLM32490831 10.5152/dir.2019.19445 NLM32490831 144512751 ppf: 363 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Resting-state fMRI analysis in apathetic Alzheimer's disease. aug: au: Büyükgök, Deniz Bayraktaroğlu, Zübeyir Buker, H. Seda Kulaksızoğlu, M. Işın Baral Gurvit, İ. Hakan Gurvit, I Hakan affil: Department of Psychiatry, Geriatric Psychiatry Unit, İstanbul University İstanbul School of Medicine, İstanbul, Turkey sug: subj: Alzheimer's Disease Relaxation Physiology Magnetic Resonance Imaging Methods Brain Middle Age Alzheimer's Disease Pathology Aged Turkiye Limbic System Case Control Studies Motivation Female Limbic System Physiopathology Aged, 80 and Over Apathy Male Brain Physiopathology Scales Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Female Male ab: Purpose: Diagnosis of comorbid psychiatric conditions are a significant determinant for the prognosis of neurodegenerative diseases. Apathy, which is a behavioral executive dysfunction, frequently accompanies Alzheimer's disease (AD) and leads to higher daily functional loss. We assume that frontal lobe hypofunction in apathetic AD patients are more apparent than the AD patients without apathy. This study aims to address the neuroanatomical correlates of apathy in the early stage of AD using task-free functional magnetic resonance imaging (MRI).Methods: Patients (n=20) were recruited from the Neurology and Psychiatry Departments of İstanbul University, İstanbul School of Medicine whose first referrals were 6- to 12-month history of progressive cognitive decline. Patients with clinical dementia rating 0.5 and 1 were included in the study. The patient group was divided into two subgroups as apathetic and non-apathetic AD according to their psychiatric examination and assessment scores. A healthy control group was also included (n=10). All subjects underwent structural and functional MRI. The resting-state condition was recorded eyes open for 5 minutes.Results: The difference between the three groups came up in the pregenual anterior cingulate cortex (pgACC) at the trend level (P = 0.056). Apathetic AD group showed the most constricted activation area at pgACC.Conclusion: The region in and around anterior default mode network (pgACC) seems to mediate motivation to initiate behavior, and this function appears to weaken as the apathy becomes more severe in AD. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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