Sex-linked neurofunctional basis of psychological resilience in late adolescence: a resting-state functional magnetic resonance imaging study.

Psychological resilience refers to the ability to adapt effectively in the face of adversity, which is closely related to an individual's psychological and physical health and well-being. Although previous behavioural studies have shown sex differences in psychological resilience, little is known ab...

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Publicado en:European Child & Adolescent Psychiatry Vol. 29; no. 8; pp. 1075 - 1088
Autores principales: Wang, Song, Yang, Cheng, Zhao, Yajun, Lai, Han, Zhang, Lei, Gong, Qiyong
Formato: diagnostic images research tables/charts Journal Article
Publicado: Springer Nature Aug2020
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Aug2020
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      pub: Springer Nature
      place: New York, New York
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        144657115
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        10.1007/s00787-019-01421-6
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        atl: Sex-linked neurofunctional basis of psychological resilience in late adolescence: a resting-state functional magnetic resonance imaging study.
      aug:
        au:
          Wang, Song
          Yang, Cheng
          Zhao, Yajun
          Lai, Han
          Zhang, Lei
          Gong, Qiyong
        affil: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, 610041, Chengdu, People's Republic of China
      sug:
        subj:
          Hardiness In Adolescence
          Adaptation, Psychological
          Sex Factors
          Neuropsychology
          Magnetic Resonance Imaging Methods
          Human
          Male
          Female
          Adolescence
          Adolescent Behavior
          Brain Physiopathology
          Anxiety
          Adolescent: 13-18 years
          Male
          Female
      ab: Psychological resilience refers to the ability to adapt effectively in the face of adversity, which is closely related to an individual's psychological and physical health and well-being. Although previous behavioural studies have shown sex differences in psychological resilience, little is known about the neural basis of sex differences in psychological resilience. Here, we measured amplitude of low-frequency fluctuations (ALFF) via resting-state functional magnetic resonance imaging to investigate the sex-linked neurofunctional basis of psychological resilience in 231 healthy adolescents. At the behavioural level, we replicated previous findings indicating that males are more resilient than females. At the neural level, we found sex differences in the relationship between psychological resilience and ALFF in the right orbitofrontal cortex (OFC). Specifically, males showed a positive correlation between psychological resilience and ALFF in the right OFC, while females showed a negative correlation in this region. The sex-specific association between psychological resilience and spontaneous brain activity might be dependent on differences in hormonal systems and brain development between male and female adolescents. Taken together, the results of our study might provide the first evidence of sex-specific neurofunctional substrates of psychological resilience in adolescents, emphasizing the vital role of sex effects in future psychological resilience-related studies.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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