Altered GABA Concentration in Brain Motor Area Is Associated with the Severity of Motor Disabilities in Individuals with Autism Spectrum Disorder.
Several motor disabilities accompanied with autism spectrum disorder (ASD) are widely known despite limited reports of underlying neural mechanisms. Gamma-aminobutyric acid (GABA) levels in the motor-related cortical areas modulate several motor performances in healthy participants. We hypothesized...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 50; no. 8; pp. 2710 - 2723 |
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| Autores principales: | , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=144696579&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 144696579 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Aug2020 vid: 50 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 144696579 144112639 144696579 144696579 10.1007/s10803-020-04382-x 144696579 ppf: 2710 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Altered GABA Concentration in Brain Motor Area Is Associated with the Severity of Motor Disabilities in Individuals with Autism Spectrum Disorder. aug: au: Umesawa, Yumi Matsushima, Kanae Atsumi, Takeshi Kato, Toshihiro Fukatsu, Reiko Wada, Makoto Ide, Masakazu affil: Department of Rehabilitation for Brain Functions, Research Institute of National Rehabilitation Center for Persons with Disabilities, 4-1, Namiki, 359-8555, Tokorozawa-shi, Saitama, Japan sug: subj: Autism Spectrum Disorder Complications GABA Cerebrospinal Fluid Frontal Lobe Analysis Severity of Disability Psychomotor Disorders Etiology Human Adolescence Adult Magnetic Resonance Spectroscopy Methods Muscle Strength Task Performance and Analysis Psychomotor Disorders Diagnosis Adolescent: 13-18 years Adult: 19-44 years ab: Several motor disabilities accompanied with autism spectrum disorder (ASD) are widely known despite limited reports of underlying neural mechanisms. Gamma-aminobutyric acid (GABA) levels in the motor-related cortical areas modulate several motor performances in healthy participants. We hypothesized that abnormal GABA concentrations in the primary motor area (M1) and supplementary motor area (SMA) associate with different motor difficulties for ASD adolescents/adults. We found that increased GABA concentrations in M1 measured using 1H-magnetic resonance spectroscopy exhibited lower motor performance in tasks requiring increased muscle strength while lower GABA concentrations in SMA were associated with lower scores in tests measuring body coordination. The degrees of neural inhibition in the M1 and SMA regions would contribute to different dimensions of motor disabilities in autism. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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