Post-exertional symptoms distinguish Myalgic Encephalomyelitis/Chronic Fatigue Syndrome subjects from healthy controls.
BACKGROUND: Post-exertional malaise (PEM) is an exacerbation of symptoms that leads to a reduction in functionality. Recognition of PEM is important for the diagnosis and treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). OBJECTIVE: Symptoms following cardiopulmonary exercise...
| Published in: | Work Vol. 66; no. 2; pp. 265 - 276 |
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| Main Authors: | , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Sage Publications Inc.
2020
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=144715326&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 144715326 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10519815 3RC jtl: Work issn: 10519815 maglogo: N pubinfo: dt: 2020 vid: 66 iid: 2 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 144715326 144715326 147563869 144715326 10.3233/WOR-203168 144715326 ppf: 265 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Post-exertional symptoms distinguish Myalgic Encephalomyelitis/Chronic Fatigue Syndrome subjects from healthy controls. aug: au: Mateo, Lariel J. Chu, Lily Stevens, Staci Stevens, Jared Snell, Christopher R. Davenport, Todd VanNess, J. Mark Mooney, Amy affil: University of the Pacific, Stockton, CA, USA sug: subj: Exercise Test, Cardiopulmonary Recovery, Exercise Fatigue Syndrome, Chronic Symptoms Human Open-Ended Questionnaires Descriptive Statistics Comparative Studies Exercise Physiology Cognition Disorders Sleep Disorders Functional Status United States Data Analysis Software T-Tests Fisher's Exact Test Post Hoc Analysis Adult Middle Age Quantitative Studies Qualitative Studies Male Female Recovery Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: BACKGROUND: Post-exertional malaise (PEM) is an exacerbation of symptoms that leads to a reduction in functionality. Recognition of PEM is important for the diagnosis and treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). OBJECTIVE: Symptoms following cardiopulmonary exercise testing were compared between ME/CFS patients and healthy controls. METHODS: Open-ended questionnaires were provided to subjects following two maximal exercise tests, 24 hours apart. Subjects evaluated how they felt at five time points. Responses were classified into 19 symptom categories. RESULTS: ME/CFS subjects (n = 49) reported an average of 14±7 symptoms compared to 4±3 by controls (n = 10). During the seven days afterwards, ME/CFS subjects reported 4±3 symptoms. None were reported by controls. Fatigue, cognitive dysfunction, and sleep problems were reported with the greatest frequency. ME/CFS patients reported more symptom categories at higher frequencies than controls. The largest differences were observed in cognitive dysfunction, decrease in function, and positive feelings. CONCLUSIONS: A standardized exertional stimulus produced prolonged, diverse symptoms in ME/CFS subjects. This provides clues to the underlying pathophysiology of ME/CFS, leading to improved diagnosis and treatment. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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