White matter microstructure varies with post-traumatic stress severity following medical trauma.
The prefrontal cortex, amygdala, hippocampus, and hypothalamus are important components of the neural network that mediates the healthy learning, expression, and regulation of emotion. These brain regions are connected by white matter pathways that include the cingulum bundle, uncinate fasciculus, a...
| Publicado en: | Brain Imaging & Behavior Vol. 14; no. 4; pp. 1012 - 1025 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Aug2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=144744846&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 144744846 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Aug2020 vid: 14 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 144744846 143976482 144744846 NLM30519996 10.1007/s11682-018-9995-9 NLM30519996 144744846 ppf: 1012 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: White matter microstructure varies with post-traumatic stress severity following medical trauma. aug: au: Harnett, Nathaniel G. Ference III, Edward W. Knight, Amy J. Knight, David C. Ference, Edward W 3rd affil: Department of Psychology, University of Alabama at Birmingham, CIRC 235H, 1720 2nd Avenue South, 35294, Birmingham, AL, USA sug: subj: Stress Disorders, Post-Traumatic Brain Magnetic Resonance Imaging ab: The prefrontal cortex, amygdala, hippocampus, and hypothalamus are important components of the neural network that mediates the healthy learning, expression, and regulation of emotion. These brain regions are connected by white matter pathways that include the cingulum bundle, uncinate fasciculus, and fornix/stria terminalis. Individuals with trauma and stress-related disorders show dysfunction of the cognitive-affective processes supported by the brain regions these white matter tracts connect. Therefore, variability in the microstructure of these white matter pathways may play an important role in the cognitive-affective dysfunction related to post-traumatic stress disorder. Thus, the current study used diffusion weighted imaging to assess the white matter microstructure of the cingulum bundle, uncinate fasciculus, and fornix/stria terminalis acutely (< 1 month) following trauma. Further, we assessed both acute (i.e., < 1 month) and subacute (i.e., 3 months post-trauma) post-traumatic stress symptom severity. White matter microstructure (assessed < 1 month post-trauma) of the uncinate fasciculus and fornix/stria terminalis varied with acute post-traumatic stress severity (assessed < 1 month post-trauma). Further, white matter microstructure (assessed < 1 month post-trauma) of the cingulum bundle and fornix/stria terminalis varied with subacute post-traumatic stress severity (assessed 3 months post-trauma). The current results suggest white matter architecture of the prefrontal cortex - amygdala network plays an important role in the development of trauma and stress-related disorders. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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