Occupational exposure of pharmacy technicians and cleaning staff to cytotoxic drugs in Dutch hospitals.
Many studies into surface contamination of hospital environments have demonstrated that occupational exposure to cytotoxics through the dermal route remains a possible risk. In this study, we assess the actual dermal exposure of the hands of pharmacy technicians and cleaning personnel in a panel of...
| Publicado en: | Journal of Occupational & Environmental Hygiene Vol. 17; no. 7/8; pp. 343 - 353 |
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| Autores principales: | , , , , , |
| Formato: | CEU questionnaire/scale research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Jul-Aug2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=144785915&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 144785915 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15459624 V1L jtl: Journal of Occupational & Environmental Hygiene issn: 15459624 maglogo: Y pubinfo: dt: Jul-Aug2020 vid: 17 iid: 7/8 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 144785915 144785915 144785915 10.1080/15459624.2020.1776299 144785915 ppf: 343 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Occupational exposure of pharmacy technicians and cleaning staff to cytotoxic drugs in Dutch hospitals. aug: au: Crul, Mirjam Hilhorst, Simone Breukels, Oscar Bouman-d'Onofrio, Johanna R. C. Stubbs, Percival van Rooij, Joost G. affil: Department of Clinical Pharmacology and Pharmacy, Amsterdam University Medical Center, Amsterdam, The Netherlands sug: subj: Hospitals Netherlands Antineoplastic Agents Pharmacy Technicians Housekeeping Department Occupational Exposure Evaluation Hand Task Performance and Analysis Human Netherlands Cyclophosphamide Handwashing Descriptive Statistics Gloves Occupational Safety Education, Continuing (Credit) ab: Many studies into surface contamination of hospital environments have demonstrated that occupational exposure to cytotoxics through the dermal route remains a possible risk. In this study, we assess the actual dermal exposure of the hands of pharmacy technicians and cleaning personnel in a panel of hospitals performing tasks that pose a risk of exposure. We compare the dermal exposure to a tentative limit value for cyclophosphamide. Pharmacy technicians and cleaning personnel were asked for hand rinsing after performance of nine tasks previously identified as posing a risk of occupational exposure. All samples were analyzed for the presence and quantity of eight antineoplastic drugs. By using data on both the frequency of the performance of the tasks and the measured dermal contamination during these tasks, weekly exposure to the marker drug (cyclophosphamide) was calculated. In five Dutch hospitals, 70 hand rinse samples and 8 blanks were collected. These were analyzed and results were used to calculate weekly exposure. The tentative limit value used was 0.74 µg of cyclophosphamide. For cleaning personnel, all results remained below this threshold value. For pharmacy technicians, the compounding itself also remained well below the limit; however, the task involving preparatory work, as well as the checking of compounded drugs, had a 13% chance of exceeding the limit. All of the highest values were found when employees were not wearing gloves on these tasks. Cleaning personnel and pharmacy technicians compounding cytotoxic drugs in our study were sufficiently protected from occupational exposure. In contrast, pharmacy technicians who perform preparatory and finishing tasks (before and after the actual compounding) are not protected enough when they do not wear gloves. pubtype: Academic Journal doctype: CEU questionnaire/scale research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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