Pharmacology, Phytochemistry, and Toxicity Profiles of Phytolacca dodecandra L'Hér: A Scoping Review.
Introduction: Phytolacca dodecandra L'Hér. is a native plant of sub-Saharan Africa and Madagascar which is traditionally used for various ailments. Concerned with the scope of the available evidence, we designed a scoping review to critically analyze scientific evidence on P dodecandra 's pharmacolo...
| Publicado en: | Infectious Diseases: Research & Treatment Vol. 13; pp. 1 - 8 |
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| Autores principales: | , , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
7/27/2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=144826359&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 144826359 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11786337 B3L6 jtl: Infectious Diseases: Research & Treatment issn: 11786337 maglogo: Y pubinfo: dt: 7/27/2020 vid: 13 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 144826359 144826359 144826359 10.1177/1178633720943509 144826359 ppf: 1 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Pharmacology, Phytochemistry, and Toxicity Profiles of Phytolacca dodecandra L'Hér: A Scoping Review. aug: au: Beressa, Tamirat Bekele Ajayi, Clement Olusoji Peter, Emanuel L Okella, Hedmon Ogwang, Patrick Engeu Anke, Weisheit Tolo, Casim Umba affil: Pharm-Bio Technology and Traditional Medicine Centre of excellence, Mbarara University of Science and Technology, Mbarara, Uganda sug: subj: Plant Extracts Pharmacodynamics Plant Extracts Analysis Phytochemicals Analysis Human Systematic Review Medline Embase Berries Analysis Escherichia Coli Drug Effects Staphylococcus Aureus Drug Effects Salmonella Drug Effects Pseudomonas Drug Effects Methanol Plant Roots Pharmacodynamics Candida Albicans Drug Effects Cryptococcus Drug Effects Glycosides Analysis Terpenes Analysis Phenols Analysis Plant Leaves Analysis Plant Bark Analysis Mollusca Drug Effects Helminths Drug Effects ab: Introduction: Phytolacca dodecandra L'Hér. is a native plant of sub-Saharan Africa and Madagascar which is traditionally used for various ailments. Concerned with the scope of the available evidence, we designed a scoping review to critically analyze scientific evidence on P dodecandra 's pharmacology, toxicity, and phytochemistry to validate its ethnomedical use. Methods: We searched without language restriction in MEDLINE, Google Scholar, Scopus, Embase, and Web of Science through December 2019. Both published and unpublished articles were assessed for relevance and reviewed. Results: Of 600 articles retrieved through database search, a total of 48 articles were finally included. The butanol extract of berries was more potent molluscicidal than aqueous extract. The berries had also miracidial, anthelmintic, antifungal activity, and antibacterial effect against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Salmonella spp. The methanol extracts of roots had an antifungal effect against Candida albicans, Cryptococcus neoformans, Microsporum gypseum, and Trichophyton mentagrophytes. Phytolacca dodecandra was toxic to aquatic invertebrate and fish. The fishes were up to 4 times more sensitive than snails. Saponins were the main phytoconstituent isolated from berries. Terpenoid and phenolic were abundant in leaves and bark extracts. Conclusions: Studies validated the traditional use of P dodecandra against snails, worms, and various bacterial and fungal infections. Limited phytochemical data call for future research to focus on isolation of compounds; test their toxicity and activity; and establish mechanism of action. pubtype: Academic Journal doctype: research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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