Evaluation of Akkermansia muciniphila bacteria in obese and overweight type 2 diabetic patients treated with insulin or oral hypoglycemic agents comparing with healthy subjects.
Background: There is a significant relationship between human intestinal bacteria and overweight, obesity and diabetes. The aim of this study was to evaluate the abundance of Akkermansia muciniphila, a bacterium residing in the mucosal layer in obese and overweight type 2 diabetic patients undergoin...
| Publicado en: | Medical Journal of Tabriz University of Medical Sciences & Health Services Vol. 42; no. 3; pp. 303 - 310 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Tabriz University of Medical Sciences
Aug/Sep2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=144916613&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 144916613 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16085671 EUW8 jtl: Medical Journal of Tabriz University of Medical Sciences & Health Services issn: 16085671 maglogo: N pubinfo: dt: Aug/Sep2020 vid: 42 iid: 3 pid: 69573 pub: Tabriz University of Medical Sciences artinfo: ui: 144916613 144916613 144916613 10.34172/mj.2020.049 144916613 ppf: 303 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Evaluation of Akkermansia muciniphila bacteria in obese and overweight type 2 diabetic patients treated with insulin or oral hypoglycemic agents comparing with healthy subjects. aug: au: Gadery, Zhila Mobassery, Majid Ostadrahimy, Ali Reza affil: Department of Internal Medicine, Imam Reza Hospital, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran sug: subj: Bacterial Infections Diagnosis Mucous Membrane Microbiology Diabetes Mellitus, Type 2 Prevention and Control Administration, Oral Insulin Administration and Dosage Hypoglycemic Agents Administration and Dosage Diabetic Patients Obesity Diagnosis Human Glucose Intolerance Drug Therapy Male Female Lipids Blood Blood Glucose Analysis Fasting Cholesterol Blood Triglycerides Blood Colony-Forming Units Assay Non-Smokers Male Female ab: Background: There is a significant relationship between human intestinal bacteria and overweight, obesity and diabetes. The aim of this study was to evaluate the abundance of Akkermansia muciniphila, a bacterium residing in the mucosal layer in obese and overweight type 2 diabetic patients undergoing insulin therapy or oral hypoglycemic agents comparing with healthy individuals. Methods: Forty insulin-dependent diabetic patients, 40 diabetic patients who were treated with oral hypoglycemic agents and 40 healthy people were recruited based on inclusion/exclusion criteria and they were evaluated for lipid profile, fasting blood sugar (FBS), and Akkermansia muciniphila bacterium. Results: The majority of all study subjects were women, non-smokers with more than four hours activity a day. They were not different in terms of demographic characteristics. FBS level was significantly higher in subjects with type 2 diabetes than in healthy subjects (P <0.001) with no significant difference in cholesterol and triglyceride levels. Cycle threshold (CT) level in both group of diabetic patients was significantly higher than that of healthy subjects (P< .001) and there was a significant difference between two groups of diabetic patients and health subjects in terms of colony-forming unit (CFU), P = 0.001. Conclusion: Akkermansia muciniphila abundance was higher in the healthy subjects comparing with diabetic patients and it was significantly greater in the patients treated with insulin than those who taken oral medications with beneficial metabolic effects, such as lowering FBS levels. There was no significant difference between all three study groups in terms of triglyceride, cholesterol, and BMI. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: Persian refInfo: holdings: @attributes: islocal: N |
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