Real-world data on new users of atypical antipsychotics: characterisation, prescription patterns, healthcare costs and early cardio-metabolic occurrences from a large Italian database.
Purpose: To describe new users of atypical antipsychotics (APs) in terms of sociodemographic characteristics, cardio-metabolic risk profile, prescription patterns, healthcare costs and cardio-metabolic events over the 24 months after treatment initiation. Methods: Atypical AP new users were selected...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 76; no. 9; pp. 1301 - 1311 |
|---|---|
| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2020
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=145048858&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 145048858 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Sep2020 vid: 76 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 145048858 144150264 145048858 145048858 10.1007/s00228-020-02899-9 145048858 ppf: 1301 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Real-world data on new users of atypical antipsychotics: characterisation, prescription patterns, healthcare costs and early cardio-metabolic occurrences from a large Italian database. aug: au: Piccinni, Carlo Dondi, Letizia Ronconi, Giulia Calabria, Silvia Esposito, Immacolata Pedrini, Antonella Maggioni, Aldo P. Barbui, Corrado Martini, Nello affil: Fondazione ReS (Ricerca e Salute)–Research and Health Foundation, Via Magnanelli 6/3, Casalecchio di Reno, 40033, Bologna, Italy sug: subj: Antipsychotic Agents Therapeutic Use Prescribing Patterns Health Care Costs Italy Cardiovascular Risk Factors Metabolic Diseases Risk Factors Human Female Adolescence Adult Middle Age Aged Aged, 80 and Over Italy Comparative Studies Matched Case Control Descriptive Statistics Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Female ab: Purpose: To describe new users of atypical antipsychotics (APs) in terms of sociodemographic characteristics, cardio-metabolic risk profile, prescription patterns, healthcare costs and cardio-metabolic events over the 24 months after treatment initiation. Methods: Atypical AP new users were selected from the ReS database and grouped into three: patients already affected by cardio-metabolic diseases (group A), patients without these clinical conditions but with predisposing conditions (group B) and patients without cardio-metabolic diseases and predisposing conditions (group C). Annual prescription patterns and healthcare costs were analysed. Subjects of groups B and C were matched with controls to compare the occurrences of cardio-metabolic events over 24 months. Results: Thirty-two thousand thirty-four new users of atypical APs were selected (median age 69). The 22.3% had cardio-metabolic diseases, 14.8% had predisposing conditions and 62.9% had none of these. The 99.3% received monotherapy. The mean annual cost per patient was €2785, and the median cost was €1108. After 24 months, a cardio-metabolic event occurred in 11.5% of group B vs. 8.7% of the controls (p <.01), and in 5.0% of group C vs. 2.1% of the controls (p <.01). Conclusion: Patients treated with atypical AP were on average old and, in a non-negligible amount, with cardio-metabolic disease or predisposing conditions. New users of atypical APs showed a significantly higher likelihood to develop a cardio-metabolic event early after treatment initiation. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|