Choroidal Thickness in Different Types of Inherited Retinal Dystrophies.
Purpose: To compare the choroidal thickness among eyes with retinitis pigmentosa (RP), Stargardt disease, Usher syndrome, cone-rod dystrophy, and healthy eyes of sex- and age-matched individuals. Methods: In this comparative study, 503 eyes with RP (n = 264), cone-rod dystrophy (n = 109), Stargardt...
| Publicado en: | Journal of Ophthalmic & Vision Research Vol. 15; no. 3; pp. 351 - 362 |
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| Autores principales: | , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Knowledge E DMCC
2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=145161949&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 145161949 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20082010 AY5S jtl: Journal of Ophthalmic & Vision Research issn: 20082010 maglogo: N pubinfo: dt: 2020 vid: 15 iid: 3 pid: 35682 pub: Knowledge E DMCC artinfo: ui: 145161949 145161949 145161949 10.18502/jovr.v15i3.7454 145161949 ppf: 351 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Choroidal Thickness in Different Types of Inherited Retinal Dystrophies. aug: au: Sabbaghi, Hamideh Ahmadieh, Hamid Jalili, Jalil Behnaz, Nazanin Fakhri, Maryam Suri, Fatemeh Kheiri, Bahareh Rajabpour, Mojtaba Entezari, Morteza Daftarian, Narsis affil: Ophthalmic Epidemiology Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran sug: subj: Uvea Pathology Eye Diseases, Hereditary Physiopathology Retinitis Pigmentosa Physiopathology Stargardt Disease Physiopathology Usher's Syndrome Physiopathology Cone-Rod Dystrophies Physiopathology Age Factors Sex Factors Human Comparative Studies Tomography, Optical Coherence Methods Data Analysis Software Adult Descriptive Statistics Child, Preschool Child Adolescence Middle Age Aged Adult: 19-44 years Child, Preschool: 2-5 years Child: 6-12 years Adolescent: 13-18 years Middle Aged: 45-64 years Aged: 65+ years ab: Purpose: To compare the choroidal thickness among eyes with retinitis pigmentosa (RP), Stargardt disease, Usher syndrome, cone-rod dystrophy, and healthy eyes of sex- and age-matched individuals. Methods: In this comparative study, 503 eyes with RP (n = 264), cone-rod dystrophy (n = 109), Stargardt disease (n = 76), and Usher syndrome (n = 54) were included. To validate the data, 109 healthy eyes of 56 sex- and age-matched individuals were studied as controls. Choroidal imaging was performed using enhanced depth imaging-optical coherence tomography. Choroidal thickness was measured manually using MATLAB software at 13 points in nasal and temporal directions from the foveal center with the interval of 500 pm and the choroidal area encompassing the measured points was calculated automatically. Results: The mean age was 36.33 ± 13.07 years (range, 5 to 72 years). The mean choroidal thickness at 13 points of the control eyes was statistically significantly higher than that in eyes with RP (P < 0.001) and Usher syndrome (P < 0.05), but not significantly different from that in eyes with Stargardt disease and cone-rod dystrophy. Among different inherited retinal dystrophies (IRDs), the choroidal thickness was the lowest in eyes with RP (P < 0.001). Choroidal thickness in the subfoveal area correlated negatively with best-corrected visual acuity (r = -0.264, P < 0.001) and the duration of ocular symptoms (r = -0.341, P < 0.001) in all studied IRDs. No significant correlation was observed between the subfoveal choroidal thickness and central macular thickness (r = -0.24, P = 0.576). Conclusion: Choroidal thinning in four different types of IRDs does not follow a similar pattern and depends on the type of IRD and the duration of ocular symptoms. A larger cohort is required to verify these findings. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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