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Chemical analysis of the semipurified extract of Paullinia cupana and evaluation of in vitro inhibitory effects against Helicobacter pylori.

Paullinia cupana Kunth, commonly known as guarana, is a native Brazilian plant species from the Amazon area that presents various biological effects, including antimicrobial action. The aim of this study was to chemically analyse the semipurified aqueous extract (AqF) of the plant and to evaluate th...

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Publicado en:Natural Product Research Vol. 34; no. 16; pp. 2332 - 2336
Autores principales: Aguiar, Bruna Aparecida Alves, Bueno, Fernanda Giacomini, Panizzon, Gean, Silva, Denise Brentan da, Athaydes, Brena Ramos, Gonçalves, Rita de Cassia Ribeiro, Kitagawa, Rodrigo Rezende, Marques, Leila Larisa Medeiros, Paula, Mariana Nascimento de, Antonelli-Ushirobira, Tânia Mara, Medeiros, Daniela Cristina de, Mello, João Carlos Palazzo de
Formato: Journal Article
Publicado: Taylor & Francis Ltd Aug2020
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Aug2020
      vid: 34
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      pub: Taylor & Francis Ltd
      place: Philadelphia, Pennsylvania
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        10.1080/14786419.2018.1533825
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        atl: Chemical analysis of the semipurified extract of Paullinia cupana and evaluation of in vitro inhibitory effects against Helicobacter pylori.
      aug:
        au:
          Aguiar, Bruna Aparecida Alves
          Bueno, Fernanda Giacomini
          Panizzon, Gean
          Silva, Denise Brentan da
          Athaydes, Brena Ramos
          Gonçalves, Rita de Cassia Ribeiro
          Kitagawa, Rodrigo Rezende
          Marques, Leila Larisa Medeiros
          Paula, Mariana Nascimento de
          Antonelli-Ushirobira, Tânia Mara
          Medeiros, Daniela Cristina de
          Mello, João Carlos Palazzo de
        affil: Laboratory of Pharmaceutical Biology, Palafito, Department of Pharmacy, State University of Maringá - UEM, Maringá, PR, Brazil
      sug:
      ab: Paullinia cupana Kunth, commonly known as guarana, is a native Brazilian plant species from the Amazon area that presents various biological effects, including antimicrobial action. The aim of this study was to chemically analyse the semipurified aqueous extract (AqF) of the plant and to evaluate the activity of crude (CE), ethyl-acetate (EAF), and AqF extracts against Helicobacter pylori. The chemical profile of AqF was determined based on solid analysis 13C-NMR, direct infusion mass spectrometry (ESI-MS), and MALDI-TOF. The 13C-NMR spectrum showed characteristics of flavan-3-ol and oligomeric proanthocyanidins. ESI-MS revealed the presence of procyanidin, caffeic acid and its derivatives. MALDI-TOF analysis detected procyanidins of up to 6 units and profisetinidins of up to 5 units. Whereas CE and EAF showed inhibitory activity against H. pylori, CE, EAF, and AqF presented not high inhibitory activity against urease. The results demonstrate the potential of P. cupana to control and prevent H. pylori infection.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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