Quantification of liver fat content in liver and primary liver lesions using triple-echo-gradient-echo MRI.
Objectives: To quantify and compare the fat fraction of background liver and primary liver lesions using a triple-echo-gradient-echo sequence. M&M: This IRB-approved study included 128 consecutive patients who underwent a liver MRI for lesion characterization. Fat fraction from the whole lesion volu...
| Publicado en: | European Radiology Vol. 30; no. 9; pp. 4752 - 4762 |
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| Autores principales: | , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=145263112&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 145263112 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Sep2020 vid: 30 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 145263112 143993486 145263112 NLM32318848 145263112 10.1007/s00330-020-06757-1 NLM32318848 145263112 ppf: 4752 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Quantification of liver fat content in liver and primary liver lesions using triple-echo-gradient-echo MRI. aug: au: Nougaret, Stephanie Monsonis, Benjamin Molinari, Nicolas Riviere, Benjamin Piron, Lauranne Kassam, Zahra Cassinotto, Christophe Guiu, Boris affil: IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM, U1194, Montpellier, France sug: subj: Carcinoma, Hepatocellular Magnetic Resonance Imaging Methods Liver Diseases Liver Neoplasms Fatty Liver Adult Middle Age Aged Retrospective Design Female Aged, 80 and Over Young Adult Contrast Media Diagnosis, Differential Sensitivity and Specificity Male Human Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Female Male ab: Objectives: To quantify and compare the fat fraction of background liver and primary liver lesions using a triple-echo-gradient-echo sequence. M&M: This IRB-approved study included 128 consecutive patients who underwent a liver MRI for lesion characterization. Fat fraction from the whole lesion volume and the normal liver parenchyma were computed from triple-echo (consecutive in-phase, opposed-phase, in-phase echo times) sequence.Results: Forty-seven hepatocellular carcinoma (HCCs), 25 hepatocellular adenomas (HCAs), and 56 focal nodular hyperplasia (FNH) were included. The mean intralesional fat fraction for various lesions was 7.1% (range, 0.5-23.6; SD, 5.6) for HCAs, 5.7% (range, 0.8-14; SD, 2.9) for HCCs, and 2.3% (range, 0.8-10.3; SD, 1.9) for FNHs (p = 0.6 for HCCs vs HCA, p < 0.001 for FNH vs HCCs or HCA). A fat fraction threshold of 2.7% enabled distinction between HCA and FNH with a sensitivity of 80% and a specificity of 77%. The mean normal liver parenchyma fat fraction was lower than the intralesional fat fraction in the HCC group (p = 0.04) and higher in the FNH group (p = 0.001), but not significantly different in the HCA group (p = 0.51).Conclusion: Triple-echo-gradient-echo is a feasible technique to quantify fat fraction of background liver and primary liver lesions. Intralesional fat fraction obtained from lesion whole volume is greater for HCCs and HCA compared to FNH. When trying to distinguish FNH and HCA, an intralesional fat fraction < 2.7% may orient toward the diagnosis of FNH.Key Points: • Triple-echo technique is feasible to quantify intralesional fat fraction of primary liver lesions. • Whole volume intralesional fat fraction is greater for HCCs and HCA compared to FNH. • An intralesional fat fraction < 2.7% may orient toward the diagnosis of FNH. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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