Age demographics of subjects enrolled in interventional phase 3 multiple myeloma clinical trials.
The mean and median ages of diagnosis of multiple myeloma range from 70 to 73 years old, with 63% of patients being over the age of 65. Phase 3 clinical trials are designed to study efficacy in the target disease population and are meant to have the most representative subject pool. The purpose of t...
| Publicado en: | Journal of Oncology Pharmacy Practice Vol. 26; no. 6; pp. 1475 - 1482 |
|---|---|
| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
Sep2020
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=145281636&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 145281636 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10781552 0JI jtl: Journal of Oncology Pharmacy Practice issn: 10781552 maglogo: Y pubinfo: dt: Sep2020 vid: 26 iid: 6 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 145281636 145281636 146261903 145281636 10.1177/1078155220934162 145281636 ppf: 1475 ppct: 7 formats: tig: atl: Age demographics of subjects enrolled in interventional phase 3 multiple myeloma clinical trials. aug: au: Borad, Abhilasha Saeed, Hamnah Toscani, Michael Barone, Joseph Weber, Paul affil: Ernest Mario School of Pharmacy at Rutgers, The State University of New Jersey, NJ, USA sug: subj: Age Factors Clinical Trials Multiple Myeloma Therapy Research Subjects Research Subject Recruitment Human Oncologic Care Geriatrics ab: The mean and median ages of diagnosis of multiple myeloma range from 70 to 73 years old, with 63% of patients being over the age of 65. Phase 3 clinical trials are designed to study efficacy in the target disease population and are meant to have the most representative subject pool. The purpose of this review is to identify the age demographic of subjects participating in interventional phase 3 clinical trials that aim to treat multiple myeloma and to determine if they encompass the true age demographic of the disease. To complete this review, a search of phase 3 multiple myeloma research trials with reported results was conducted on clinicaltrials.gov, a national, publicly available resource listing clinical trials. Reported mean or median ages of subjects were identified for each trial, and adjusted averages of these values were calculated. Data from 81 clinical trials were assessed, with 42 trials reporting an average mean age of 65.78 years and 15 trials reporting an average median age of 63.29 years. Based on these results, it was determined that the clinical trials reported in this study enrolled patients that were younger than the true age demographic of the disease. There is an unmet need in research in the older population of patients with multiple myeloma, and this may hinder the generalizability and utility of clinical trial results. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|