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Seroprevalence of Anti– Toxoplasma gondii Antibodies and Associated Factors Among Pregnant Women Attending Antenatal Care at Debre Markos Referral Hospital, Northwest Ethiopia.

Background: Toxoplasma gondii is an obligate intracellular protozoan parasite that causes a zoonotic disease called toxoplasmosis. If the infection acquired during pregnancy is not detected and treated early, the parasite can be transmitted transplacentally to the fetus, resulting in congenital toxo...

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Published in:Infectious Diseases: Research & Treatment Vol. 13; pp. 1 - 11
Main Authors: Mulugeta, Senait, Munshea, Abaineh, Nibret, Endalkachew
Format: research tables/charts Journal Article
Published: Sage Publications Inc. 8/24/2020
Online Access:View this record in EBSCOhost
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        11786337
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      jtl: Infectious Diseases: Research & Treatment
      issn: 11786337
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    pubinfo:
      dt: 8/24/2020
      vid: 13
      pid: 344
      pub: Sage Publications Inc.
      place: Thousand Oaks, California
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        145322901
        145322901
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        10.1177/1178633720948872
        145322901
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        atl: Seroprevalence of Anti– Toxoplasma gondii Antibodies and Associated Factors Among Pregnant Women Attending Antenatal Care at Debre Markos Referral Hospital, Northwest Ethiopia.
      aug:
        au:
          Mulugeta, Senait
          Munshea, Abaineh
          Nibret, Endalkachew
        affil: Biology Department, Bahir Dar University, Bahir Dar, Ethiopia
      sug:
        subj:
          Seroprevalence Studies
          Toxoplasmosis Risk Factors
          Antibodies
          Expectant Mothers
          Prenatal Care
          Hospitals Ethiopia
          Human
          Ethiopia
          Cross Sectional Studies
          Structured Questionnaires
          Agglutination Tests
          Logistic Regression
          Descriptive Statistics
          Multivariate Analysis
          Odds Ratio
          Confidence Intervals
      ab: Background: Toxoplasma gondii is an obligate intracellular protozoan parasite that causes a zoonotic disease called toxoplasmosis. If the infection acquired during pregnancy is not detected and treated early, the parasite can be transmitted transplacentally to the fetus, resulting in congenital toxoplasmosis, which likely leads to serious consequences in the fetus. Toxoplasmosis constitutes a major public health problem particularly in low- and middle-income countries including Ethiopia. This study aimed to determine the seroprevalence and to assess the potential risk factors of toxoplasmosis among pregnant women attending antenatal care at Debre Markos Referral Hospital, Northwest Ethiopia. Methods: In this cross-sectional study, data on the sociodemographic and potential obstetric and behavioral risk factors were gathered through pretested structured questionnaires, and 3 mL of venous blood was also drawn from each of randomly selected 233 study subjects. The serum samples were separated from the blood samples and tested for anti- Toxoplasma antibody using Toxo-latex slide agglutination test. Logistic regression analysis was used to examine the association between risk factors considered and T gondii infection. Results: The overall prevalence of T gondii infection was 67.8%, indicating a high prevalence of toxoplasmosis in the study area. In multivariate analysis, keeping domestic cat at home was found to be the only explanatory variable of toxoplasmosis (adjusted odds ratio = 2.449, 95% confidence interval = 1.183-5.070, P =.016). All sociodemographic variables and most of the potential obstetric and behavioral risk factors were not statistically significant explanatory variables of T gondii infection. Conclusion: The prevalence of toxoplasmosis is high in the study area. Thus, pregnant women should be aware of the potential risk of the disease when keeping cats at home and management of their litter. Inclusion of serologic screening for T gondii infection at antenatal care is warranted for prevention of congenital toxoplasmosis.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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