Mapping the relationships between inflammatory bowel disease and comorbid diagnoses to identify disease associations.
Background: Massive amounts of patient data are captured daily in electronic medical records (EMR). Utilizing the power of such large data may help identify disease associations and generate hypotheses that can lead to a better understanding of disease associations and mechanisms. We aimed to compre...
| Publicado en: | European Journal of Gastroenterology & Hepatology Vol. 32; no. 10; pp. 1341 - 1348 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Oct2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=145399782&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 145399782 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0954691X 8CE jtl: European Journal of Gastroenterology & Hepatology issn: 0954691X maglogo: N pubinfo: dt: Oct2020 vid: 32 iid: 10 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 145399782 145399782 NLM32804850 10.1097/MEG.0000000000001869 NLM32804850 145399782 ppf: 1341 ppct: 7 formats: tig: atl: Mapping the relationships between inflammatory bowel disease and comorbid diagnoses to identify disease associations. aug: au: Waljee, Akbar K. Noureldin, Mohamed Berinstein, Jeffrey A. Cohen-Mekelburg, Shirley A. Wallace, Beth I. Cushing, Kelly C. Hanauer, David A. Keeney-Bonthrone, Toby P. Nallamothu, Brahmajee Higgins, Peter D.R. affil: VA Center for Clinical Management Research, VA Ann Arbor Health Care System sug: subj: Pyoderma Gangrenosum Inflammatory Bowel Diseases Epidemiology Erythema Nodosum Inflammatory Bowel Diseases Diagnosis Colitis Female Cross Sectional Studies Female ab: Background: Massive amounts of patient data are captured daily in electronic medical records (EMR). Utilizing the power of such large data may help identify disease associations and generate hypotheses that can lead to a better understanding of disease associations and mechanisms. We aimed to comprehensively identify and validate associations between inflammatory bowel disease (IBD) and concurrent comorbid diagnoses.Methods: We performed a cross-sectional study using EMR data collected between 1986 and 2009 at a large tertiary referral center to identify associations with a diagnosis of IBD. The resulting associations were externally validated using the Truven MarketScan database, a large nationwide dataset of private insurance claims.Results: A total of 6225 IBD patients and 31 125 non-IBD controls identified using EMR data were used to abstract 41 comorbid diagnoses associated with an IBD diagnosis. The strongest associations included Clostridiodes difficile infection, pyoderma gangrenosum, parametritis, pernicious anemia, erythema nodosum, and cytomegalovirus infection. Two IBD association clusters were found, including diagnoses of nerve conduction abnormalities and nonspecific inflammatory conditions of organs outside the gut. These associations were validated in a national cohort of 80 907 patients with IBD and 404 535 age- and sex-matched controls.Conclusion: We leveraged a big data approach to identify several associations between IBD and concurrent comorbid diagnoses. EMR and big data provide the opportunity to explore disease associations with large sample sizes. Further studies are warranted to refine the characterization of these associations and evaluate their usefulness for increasing our understanding of disease associations and mechanisms. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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