Resting Oxygen Consumption and Heart Failure: Importance of Measurement for Determination of Cardiac Output With the Use of the Fick Principle.
Background: Resting oxygen consumption (VO2) is often estimated and frequently used to guide therapeutic decisions in symptomatic heart failure (HF) patients. The relationship between resting VO2 and symptomatic HF and the accuracy of estimations of VO2 in this population are unknown.Methods and Res...
| Publicado en: | Journal of Cardiac Failure Vol. 26; no. 8; pp. 664 - 673 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
W B Saunders
Aug2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=145409985&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 145409985 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10719164 DOP jtl: Journal of Cardiac Failure issn: 10719164 maglogo: N pubinfo: dt: Aug2020 vid: 26 iid: 8 pid: 1351 pub: W B Saunders place: Philadelphia, Pennsylvania artinfo: ui: 145409985 145409985 NLM30753933 10.1016/j.cardfail.2019.02.004 NLM30753933 145409985 ppf: 664 ppct: 9 formats: tig: atl: Resting Oxygen Consumption and Heart Failure: Importance of Measurement for Determination of Cardiac Output With the Use of the Fick Principle. aug: au: Grafton, Gillian Cascino, Thomas M. Perry, Daniel Ashur, Carmel Koelling, Todd M. affil: Division of Cardiovascular Medicine, Henry Ford, Detroit, Michigan sug: subj: Heart Failure Diagnosis Oxygen Consumption Oxygen Thermodilution Cross Sectional Studies Cardiac Output Clinical Assessment Tools Impact of Events Scale ab: Background: Resting oxygen consumption (VO2) is often estimated and frequently used to guide therapeutic decisions in symptomatic heart failure (HF) patients. The relationship between resting VO2 and symptomatic HF and the accuracy of estimations of VO2 in this population are unknown.Methods and Results: We performed a cross-sectional study of HF patients (n = 691) and healthy control subjects (n = 77). VO2 was measured with the use of a metabolic cart, and estimated VO2 was calculated with the use of the Dehmer, LaFarge, and Bergstra formulas and the thermodilution method. The measured and estimated VO2 were compared and the potential impact of estimations determined. In the multivariable model, resting VO2 decreased with increasing New York Heart Association (NYHA) functional class in a stepwise fashion (β NYHA functional class IV vs control = -36 mL O2/min; P < .001). Estimations of VO2 with the use of derived equations diverged from measured values, particularly for patients with NYHA functional class IV limitations. The percentage difference of measured VO2 versus estimated VO2 was >25% in 39% (n = 271), 25% (n = 170), 82% (n = 566), and 39% (n = 271) of HF patients when using the Dehmer, LaFarge, Bergstra, and thermodilution-derived estimations of VO2 respectively.Conclusions: Resting VO2 decreases with increasing NYHA functional class and is lower than in control subjects. Using estimations of VO2 to calculate CO may introduce clinically important error. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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