Pharmacokinetics, Safety, and Tolerability of Selonsertib, an Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitor, Following First-in-Human Single and Multiple Ascending Doses in Healthy Subjects.

Background: Selonsertib is a first-in-class inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with therapeutic potential for fibrotic diseases. This phase I study evaluated the safety, tolerability, pharmacokinetics (PK), and food effect of selonsertib in healthy subjects.Methods: This was a...

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Bibliographic Details

Published in:	Clinical Pharmacokinetics Vol. 59; no. 9; pp. 1109 - 1118
Main Authors:	Nelson, Cara H., Etchevers, Kim, Yi, Saili, Breckenridge, David, Hepner, Mischa, Patel, Uptal, Ling, John, Mathias, Anita
Format:	research Journal Article
Published:	Springer Nature Sep2020
Online Access:	View this record in EBSCOhost