The Predictive Value of Serum Cytokines for Distinguishing Celiac Disease from Non-Celiac Gluten Sensitivity and Healthy Subjects.
Background: It has been established that the level of some inflammatory cytokines increases in celiac disease (CD) and non-celiac gluten sensitivity (NCGS) in comparison with healthy subjects. Therefore, the primary interest in our research was proposing an accurate tool to diagnose patients with CD...
| Publicado en: | Iranian Biomedical Journal Vol. 24; no. 6; pp. 335 - 342 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Pasteur Institute of Iran
Nov2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=145469356&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 145469356 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1028852X 783E jtl: Iranian Biomedical Journal issn: 1028852X maglogo: N pubinfo: dt: Nov2020 vid: 24 iid: 6 pid: 47405 pub: Pasteur Institute of Iran artinfo: ui: 145469356 145469356 NLM32660201 10.29252/ibj.24.6.335 NLM32660201 145469356 ppf: 335 ppct: 7 formats: tig: atl: The Predictive Value of Serum Cytokines for Distinguishing Celiac Disease from Non-Celiac Gluten Sensitivity and Healthy Subjects. aug: au: Masaebi, Fatemeh Looha, Mehdi Azizmohammad Rostami-Nejad, Mohammad Pourhoseingholi, Mohamad Amin Mohseni, Navid Samasca, Gabriel Lupan, Iulia Rezaei-Tavirani, Mostafa Zali, Mohammad Reza Azizmohammad Looha, Mehdi affil: Department of Biostatistics, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran sug: subj: Celiac Disease Blood Celiac Disease Diagnosis Cytokines Blood Research Subjects Gluten Adverse Effects Case Control Studies Diagnosis, Differential Male Predictive Value of Tests ROC Curve Female Adult Scales Adult: 19-44 years Male Female ab: Background: It has been established that the level of some inflammatory cytokines increases in celiac disease (CD) and non-celiac gluten sensitivity (NCGS) in comparison with healthy subjects. Therefore, the primary interest in our research was proposing an accurate tool to diagnose patients with CD and NCGS from healthy individuals in an Iranian population.Methods: The serum samples were examined in 171 participants, including 110 CD patients, 46 healthy individuals, and 15 NCGS. The commercial ELISA kits were used to detect the level of the following cytokines: IL-1, IL-6, IL-8, IL-15, and IFN-γ. The receiver operating characteristic (ROC) curve analysis was applied to determine the optimal thresholds for high sensitivity, specificity, positive and negative predictive values of cytokines, as the indicators of CD, NCGS, and healthy control groups.Results: In NCGS group, the values of area under the ROC curve for IL-1, IL-8, and IFN-γ were 71%, 78%, and 70%, respectively. To differentiate the CD and NCGS groups from the control group, IL-15 had the highest sensitivity (82.70%), specificity (56.50%), positive predictive value (81.98%), and negative predictive value (57.78%), followed by IL-8 with the highest sensitivity of 74.50%, specificity of 73.30%, and positive and negative predictive values of 95.35% and 30.21%, respectively.Conclusion: The obtained results demonstrate that IL-15 and IL-8 could be proposed as potential markers in their optimal cut-off points for distinguishing CD from the NCGS and the healthy control. Based on our findings, the evaluation of cytokine levels can be recommended as a useful tool for the diagnosis of CD and NCGS in a clinical practice. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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