Evaluation of a Correction Method for 111In-Pentetreotide SPECT Imaging of Gastroenteropancreatic Neuroendocrine Tumors.
The number of patients with the extremely rare disease gastroenteropancreatic (GEP) neuroendocrine tumor (NET) has increased rapidly in recent years. 111In-pentetreotide SPECT in somatostatin receptor scintigraphy has been used for the assessment of GEP NET patients. To diagnose GEP NET, appropriate...
| Publicado en: | Journal of Nuclear Medicine Technology Vol. 48; no. 3; pp. 1 - 31 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Society of Nuclear Medicine
Sep2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=145511496&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 145511496 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00914916 H7Q jtl: Journal of Nuclear Medicine Technology issn: 00914916 maglogo: N pubinfo: dt: Sep2020 vid: 48 iid: 3 pid: 2576 pub: Society of Nuclear Medicine place: Reston, Virginia artinfo: ui: 145511496 145511496 NLM32887762 10.2967/jnmt.120.249680 NLM32887762 145511496 ppf: 1 ppct: 30 formats: fmt: @attributes: type: P tig: atl: Evaluation of a Correction Method for 111In-Pentetreotide SPECT Imaging of Gastroenteropancreatic Neuroendocrine Tumors. aug: au: Takao Kanzaki Yasuyuki Takahashi Tetsuya Higuchi Xieyi Zhang Nao Mogi Takayuki Suto Yoshito Tsushima Kanzaki, Takao Takahashi, Yasuyuki Higuchi, Tetsuya Zhang, Xieyi Mogi, Nao Suto, Takayuki Tsushima, Yoshito affil: Department of Radiology, Gunma University Hospital 3-39-15 Showa, Maebashi, Gunma 371-8511 Japan sug: subj: Pancreatic Neoplasms Somatostatin Analogs and Derivatives Intestinal Neoplasms Neuroendocrine Tumors Stomach Neoplasms Tomography, Emission-Computed, Single-Photon Image Processing, Computer Assisted Aged Male Adult Female Middle Age Aged, 80 and Over Scales Ferrans and Powers Quality of Life Index Aged: 65+ years Adult: 19-44 years Middle Aged: 45-64 years Aged, 80 & over Male Female ab: The number of patients with the extremely rare disease gastroenteropancreatic (GEP) neuroendocrine tumor (NET) has increased rapidly in recent years. 111In-pentetreotide SPECT in somatostatin receptor scintigraphy has been used for the assessment of GEP NET patients. To diagnose GEP NET, appropriate selection of image correction parameters is critical. Correction methods may improve the 111In-pentetreotide SPECT image quality, but there is currently no standard technique. The purpose of this study was to determine the optimal correction parameter settings for 111In-pentetreotide SPECT. Methods: A phantom study produced images with a tumor-to-background ratio of as high as 16:1. A triple energy window was used for scatter correction (SC), and attenuation correction (AC) was CT-based. Correlation analysis was performed in 4 groups: no correction (NC), SC, AC, and combined SC with AC (CC). The 111In-pentetreotide SPECT results for 20 randomly selected patients (13 men and 7 women; age range, 37-81 y) with confirmed GEP NET were analyzed using data collected 4 h after injection of 111 MBq of 111In-pentetreotide. Emission data were reconstructed using ordered-subset expectation maximization (OSEM) with different settings. Different combinations of the correction parameters were used to analyze the contrast-to-noise ratios (CNRs) obtained with the phantom. In the clinical study, 20 GEP NET patients were used to evaluate the GEP NET lesion CNR by 4 different image correction methods obtained from 111In-pentetreotide SPECT images: NC, SC, AC, and CC. NC was used as a reference method. Results: The phantom study revealed that the optimal energy window in the photopeak for somatostatin receptor scintigraphy was 171 keV ± 10% and 245 keV ± 7.5%, and the optimal OSEM reconstruction conditions were 8 subsets and 6 iterations. Among the OSEM collection conditions, CC produced a significantly higher CNR than NC or SC (P < 0.05). In the clinical study, CC was found to increase the CNR (P < 0.05). Conclusion: CC improves the correction in 111In-pentetreotide SPECT studies, compared with NC, providing better contrast and sharper outlines of lesions and organs. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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