Antifungal activity study of the monoterpene thymol against Cryptococcus neoformans.
Cryptococcus neoformans is a yeast fungus, which causes cryptococcosis, triggered by basidiospore inhalation and consequent dissemination to the central nervous system. In this study, we analyzed the antifungal action of thymol against 10 clinical strains of C. neoformans and analyzed the interactio...
| Publicado en: | Natural Product Research Vol. 34; no. 18; pp. 2630 - 2634 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Taylor & Francis Ltd
Sep2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=145644689&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 145644689 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14786419 RFT jtl: Natural Product Research issn: 14786419 maglogo: Y pubinfo: dt: Sep2020 vid: 34 iid: 18 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 145644689 10.1080/14786419.2018.1547296 145644689 ppf: 2630 ppct: 4 formats: tig: atl: Antifungal activity study of the monoterpene thymol against Cryptococcus neoformans. aug: au: Teixeira, Anna Paula de Castro Nóbrega, Rafaela de Oliveira Lima, Edeltrudes de Oliveira Araújo, Wylly de Oliveira Lima, Igara de Oliveira affil: Departament of Pharmacy of Health Academic Unit, Federal University of Campina Grande, Cuité, Brazil sug: ab: Cryptococcus neoformans is a yeast fungus, which causes cryptococcosis, triggered by basidiospore inhalation and consequent dissemination to the central nervous system. In this study, we analyzed the antifungal action of thymol against 10 clinical strains of C. neoformans and analyzed the interaction of this monoterpene with sterols. The MICs of thymol ranged from 20 to 51 μg/ml, while the MFC values varied between 40 and 101 μg/ml. For the strains ICB-2601 and LM-39, in the presence of ergosterol, the MIC of thymol was 64 μg/ml, and in the presence of cholesterol, its MIC was 32 μg/ml. Based on the results, thymol presents antifungal action and seems to interact with ergosterol, but not with cholesterol. Complementary studies are needed to analyze its full effects. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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