ABCB1 and ERCC1 gene polymorphisms are associated with nephro- and hepatotoxicity to carboplatin/paclitaxel-based chemotherapy in patients with gynecologic cancers.

Background: Paclitaxel/carboplatin combination is the standard chemotherapeutic protocol for gynecologic cancers, but severe toxicities may compromise treatment. There is great inter-individual variability regarding the incidence and severity of toxicities, which may be due to single-nucleotide poly...

Full description

Bibliographic Details

Published in:	European Journal of Clinical Pharmacology Vol. 76; no. 10; pp. 1401 - 1409
Main Authors:	da Costa Junior, Luiz Carlos, de Castro, Clarissa Lourenço, Freitas-Alves, Daniely Regina, Vianna-Jorge, Rosane, Santos, Paulo Caleb Júnior Lima
Format:	research tables/charts Journal Article
Published:	Springer Nature Oct2020
Online Access:	View this record in EBSCOhost