COVID-19 in a Hispanic Woman: Autopsy Report With Clinical-Pathologic Correlation.
Since making its debut on the global stage in December 2019, coronavirus disease 2019 (COVID-19) has afflicted nearly 4 million people and caused hundreds of thousands of deaths. Case reports and case series depicting the clinical effects of the causative virus--severe acute respiratory syndrome cor...
| Publicado en: | Archives of Pathology & Laboratory Medicine Vol. 144; no. 9; pp. 1041 - 1048 |
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| Autores principales: | , , , , , , |
| Formato: | case study diagnostic images pictorial tracings Journal Article |
| Publicado: |
College of American Pathologists
Sep2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=145655958&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 145655958 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00039985 1FS jtl: Archives of Pathology & Laboratory Medicine issn: 00039985 maglogo: N pubinfo: dt: Sep2020 vid: 144 iid: 9 pid: 2550 pub: College of American Pathologists place: Northfield, Illinois artinfo: ui: 145655958 145655958 145655958 10.5858/arpa.2020-0217-SA 145655958 ppf: 1041 ppct: 7 formats: fmt: @attributes: type: P tig: atl: COVID-19 in a Hispanic Woman: Autopsy Report With Clinical-Pathologic Correlation. aug: au: Lei Yan Mir, Mahnoor Sanchez, Paloma Beg, Moeezullah Peters, Jay Enriquez, Omar Gilbert, Andrea affil: Department of Pathology and Laboratory Medicine, Long School of Medicine, University of Texas Health San Antonio sug: subj: COVID-19 Diagnosis COVID-19 Pathology Autopsy Female Middle Age Respiratory Distress Syndrome, Acute Lung Injury Pneumonia, Viral Pulmonary Edema Myocardial Diseases Middle Aged: 45-64 years Female ab: Since making its debut on the global stage in December 2019, coronavirus disease 2019 (COVID-19) has afflicted nearly 4 million people and caused hundreds of thousands of deaths. Case reports and case series depicting the clinical effects of the causative virus--severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)--have been published, yet few demonstrate the cytopathologic alterations of this disease. We present a clinical-pathologic correlation report of a previously healthy Hispanic woman with laboratory-confirmed COVID-19 who had typical features of acute respiratory distress syndrome (ARDS) and also showed cardiac abnormalities thought to represent fulminant viral myocarditis. Congruent with the ARDS clinical impression, autopsy findings were remarkable for extensive and markedly severe acute lung injury consistent with viral pneumonia, characterized by diffuse alveolar damage, pulmonary infarction, severe pulmonary edema, desquamation of pneumocytes with intra-alveolar aggregation, and pneumocyte morphologic alterations suggestive of viral cytopathic effect. However, there was incongruence between the clinical impression and the cardiovascular pathology findings in that viral myocarditis was not detected on histopathologic evaluation. This case highlights the importance of pathologic corroboration of the clinical impression and, in addition, illuminates the key role autopsy plays during a pandemic by providing valuable insight into viral pathology in tissues. pubtype: Academic Journal doctype: case study diagnostic images pictorial tracings Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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