is a tumor-suppressive and prognosis-related transcript isoform in ovarian serous cystadenocarcinoma.
Aim: To explore FBXW7 protein-coding transcript isoform (α, β and γ) expression, their functions and prognostic value in ovarian serous cystadenocarcinoma (OSC). Materials & methods:FBXW7 transcript data were collected from The Cancer Genome Atlas and the Genotype-Tissue Expression project. IOSE, A2...
| Publicado en: | Future Oncology Vol. 16; no. 25; pp. 1921 - 1931 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Taylor & Francis Ltd
Sep2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=145695176&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 145695176 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14796694 3CMQ jtl: Future Oncology issn: 14796694 maglogo: N pubinfo: dt: Sep2020 vid: 16 iid: 25 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 145695176 145695176 NLM32915667 10.2217/fon-2020-0371 NLM32915667 145695176 ppf: 1921 ppct: 10 formats: tig: atl: is a tumor-suppressive and prognosis-related transcript isoform in ovarian serous cystadenocarcinoma. aug: au: Xu, Zhou Zhuang, Lin Wang, Xiaoyin Li, Qianrong Sang, Yan Xu, Jiao affil: Department of Obstetrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, PR China sug: subj: Genes Neoplasms, Cystic, Mucinous, and Serous Etiology RNA Neoplasms, Cystic, Mucinous, and Serous Mortality Ovarian Neoplasms Etiology Mice Neoplasm Staging Models, Biological Female Ovarian Neoplasms Pathology Ovarian Neoplasms Metabolism Neoplasm Metastasis Kaplan-Meier Estimator Animals Neoplasms, Cystic, Mucinous, and Serous Metabolism Neoplasms, Cystic, Mucinous, and Serous Pathology Cell Line, Tumor Prognosis Fallopian Tubes Metabolism Female ab: Aim: To explore FBXW7 protein-coding transcript isoform (α, β and γ) expression, their functions and prognostic value in ovarian serous cystadenocarcinoma (OSC). Materials & methods:FBXW7 transcript data were collected from The Cancer Genome Atlas and the Genotype-Tissue Expression project. IOSE, A2780 and SKOV3 cells were used for in vitro and in vivo studies. Results:FBXW7α and FBXW7γ are dominant protein-coding transcripts that were downregulated in OSC. FBXW7γ overexpression reduced the protein expression of c-Myc, Notch1 and Yap1 and suppressed OSC cell growth in vitro and in vivo. FBXW7γ expression was an independent indicator of longer disease-specific survival (HR: 0.588; 95% CI: 0.449-0.770) and progression-free survival (HR: 0.708; 95% CI: 0.562-0.892). Conclusion:FBXW7γ is a tumor-suppressive and might be the only prognosis-related FBXW7 transcript in OSC. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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