High-fat diet effects on the prostatic adenocarcinoma model and jaboticaba peel extract intake: protective response in metabolic disorders and liver histopathology.
Prostate cancer (PCa), overweight and obesity are frequent worldwide health problems. Clinical studies have shown that increased high-fat diet (HFD) consumption is associated with higher incidence of PCa. Brazilian berries, such as Myrciaria jaboticaba (Vell.) Berg, present high polyphenol concentra...
| Publicado en: | Nutrition & Cancer Vol. 72; no. 8; pp. 1366 - 1378 |
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| Autores principales: | , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=145752966&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 145752966 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2020 vid: 72 iid: 8 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 145752966 145752966 145752966 10.1080/01635581.2019.1684526 145752966 ppf: 1366 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: High-fat diet effects on the prostatic adenocarcinoma model and jaboticaba peel extract intake: protective response in metabolic disorders and liver histopathology. aug: au: Nogueira-Lima, Ellen Lamas, Celina de Almeida Baseggio, Andressa Mara do Vale, Jéssica Stephany Fernandes Maróstica Junior, Mário Roberto Cagnon, Valéria Helena Alves affil: Department of Structural and Functional Biology, University of Campinas, São Paulo, Brazil sug: subj: Dietary Fats Adverse Effects Prostatic Neoplasms Complications Adenocarcinoma Complications Metabolic Diseases Prevention and Control Plant Extracts Pharmacodynamics Berries Therapeutic Use Liver Drug Effects Animal Studies Mice Liver Diseases Pathology Glucose Metabolism Insulin Metabolism Polyphenols Therapeutic Use Insulin Resistance Glucose Intolerance ab: Prostate cancer (PCa), overweight and obesity are frequent worldwide health problems. Clinical studies have shown that increased high-fat diet (HFD) consumption is associated with higher incidence of PCa. Brazilian berries, such as Myrciaria jaboticaba (Vell.) Berg, present high polyphenol concentration in the peel and exhibit positive effects on metabolic disorders and hepatic lesions. Therefore, the aim of the study herein was to investigate the patented jaboticaba peel extract effects (PJE) on different metabolic parameters and liver histopathology in the transgenic adenocarcinoma of the mouse prostate model, receiving a either normolipid diet or HFD for 8 weeks. The results showed that PJE reduced insulin resistance and glucose intolerance, decreased hepatic lipid accumulation, and inflammatory markers such as PPARγ and TNFα, respectively. In conclusion, the PJE treatment promoted protective effects in the metabolism of insulin and glucose and liver imbalance caused by HFD intake in the PCa model, suggesting that it may be a good protector against metabolic disorders present in overweight and associated with PCa. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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