Pyoderma gangrenosum: From historical perspectives to emerging investigations.
Pyoderma gangrenosum (PG) is a rare disease of unknown aetiology, first described over a century ago. Initially thought to have an infectious cause, and now primarily considered an autoinflammatory condition, PG continues to be poorly understood, commonly misdiagnosed, and difficult to treat. In thi...
| Publicado en: | International Wound Journal Vol. 17; no. 5; pp. 1255 - 1266 |
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| Autores principales: | , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Oct2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=145959093&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 145959093 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17424801 1725 jtl: International Wound Journal issn: 17424801 maglogo: Y pubinfo: dt: Oct2020 vid: 17 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 145959093 145959093 145959093 10.1111/iwj.13389 145959093 ppf: 1255 ppct: 11 formats: tig: atl: Pyoderma gangrenosum: From historical perspectives to emerging investigations. aug: au: Hobbs, Misty M. Ortega‐Loayza, Alex G. affil: Mayo Clinic, Jacksonville Florida,, USA sug: subj: Pyoderma Gangrenosum History Pyoderma Gangrenosum Diagnosis Pyoderma Gangrenosum Etiology Pyoderma Gangrenosum Pathology Pyoderma Gangrenosum Drug Therapy ab: Pyoderma gangrenosum (PG) is a rare disease of unknown aetiology, first described over a century ago. Initially thought to have an infectious cause, and now primarily considered an autoinflammatory condition, PG continues to be poorly understood, commonly misdiagnosed, and difficult to treat. In this review, we discuss the journey of our understanding of PG to date, including first descriptions, challenges with diagnosis, presumed pathogenesis, and treatments used. We highlight major historical landmarks and their importance, explain the rationale behind current investigations, note outstanding gaps in knowledge, and explore the future directions of PG research. We summarise what we have known, what we are working on knowing, and what we have yet to explore about PG, illustrating overall trends to invigorate future research. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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