An Embedded Multi-branch 3D Convolution Neural Network for False Positive Reduction in Lung Nodule Detection.

Numerous lung nodule candidates can be produced through an automated lung nodule detection system. Classifying these candidates to reduce false positives is an important step in the detection process. The objective during this paper is to predict real nodules from a large number of pulmonary nodule...

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Publicado en:Journal of Digital Imaging Vol. 33; no. 4; pp. 846 - 858
Autores principales: Zuo, Wangxia, Zhou, Fuqiang, He, Yuzhu
Formato: diagnostic images equations & formulas research tables/charts Journal Article
Publicado: Springer Nature Aug2020
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Aug2020
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s10278-020-00326-0
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        atl: An Embedded Multi-branch 3D Convolution Neural Network for False Positive Reduction in Lung Nodule Detection.
      aug:
        au:
          Zuo, Wangxia
          Zhou, Fuqiang
          He, Yuzhu
        affil: The School of Instrumentation and Optoelectronics Engineering, Beihang University, 37 Xueyuan Road, Haidian District, 100083, Beijing, China
      sug:
        subj:
          Lung Neoplasms Radiography
          Tomography, X-Ray Computed
          Imaging, Three-Dimensional
          Neural Networks (Computer)
          False Positive Results
          Diagnostic Errors Prevention and Control
          Diagnosis, Computer Assisted
          Human
          Automation
          Sensitivity and Specificity
          Lung Neoplasms Classification
          Computer Simulation
      ab: Numerous lung nodule candidates can be produced through an automated lung nodule detection system. Classifying these candidates to reduce false positives is an important step in the detection process. The objective during this paper is to predict real nodules from a large number of pulmonary nodule candidates. Facing the challenge of the classification task, we propose a novel 3D convolution neural network (CNN) to reduce false positives in lung nodule detection. The novel 3D CNN includes embedded multiple branches in its structure. Each branch processes a feature map from a layer with different depths. All of these branches are cascaded at their ends; thus, features from different depth layers are combined to predict the categories of candidates. The proposed method obtains a competitive score in lung nodule candidate classification on LUNA16 dataset with an accuracy of 0.9783, a sensitivity of 0.8771, a precision of 0.9426, and a specificity of 0.9925. Moreover, a good performance on the competition performance metric (CPM) is also obtained with a score of 0.830. As a 3D CNN, the proposed model can learn complete and three-dimensional discriminative information about nodules and non-nodules to avoid some misidentification problems caused due to lack of spatial correlation information extracted from traditional methods or 2D networks. As an embedded multi-branch structure, the model is also more effective in recognizing the nodules of various shapes and sizes. As a result, the proposed method gains a competitive score on the false positive reduction in lung nodule detection and can be used as a reference for classifying nodule candidates.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        equations & formulas
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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