Prediction of Non-small Cell Lung Cancer Histology by a Deep Ensemble of Convolutional and Bidirectional Recurrent Neural Network.

Histology subtype prediction is a major task for grading non-small cell lung cancer (NSCLC) tumors. Invasive methods such as biopsy often lack in tumor sample, and as a result radiologists or oncologists find it difficult to detect proper histology of NSCLC tumors. The non-invasive methods such as m...

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Publicado en:Journal of Digital Imaging Vol. 33; no. 4; pp. 895 - 903
Autores principales: Moitra, Dipanjan, Mandal, Rakesh Kumar
Formato: diagnostic images equations & formulas research tables/charts Journal Article
Publicado: Springer Nature Aug2020
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Aug2020
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s10278-020-00337-x
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        atl: Prediction of Non-small Cell Lung Cancer Histology by a Deep Ensemble of Convolutional and Bidirectional Recurrent Neural Network.
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          Moitra, Dipanjan
          Mandal, Rakesh Kumar
        affil: University of North Bengal, Siliguri, India
      sug:
        subj:
          Carcinoma, Non-Small-Cell Lung Pathology
          Neoplasm Grading
          Recurrent Neural Networks
          Human
          Diagnostic Imaging
          Biological Markers
          Deep Learning
          ROC Curve
          Carcinoma, Non-Small-Cell Lung Prognosis
      ab: Histology subtype prediction is a major task for grading non-small cell lung cancer (NSCLC) tumors. Invasive methods such as biopsy often lack in tumor sample, and as a result radiologists or oncologists find it difficult to detect proper histology of NSCLC tumors. The non-invasive methods such as machine learning may play a useful role to predict NSCLC histology by using medical image biomarkers. Few attempts have so far been made to predict NSCLC histology by considering all the major subtypes. The present study aimed to develop a more accurate deep learning model by clubbing convolutional and bidirectional recurrent neural networks. The NSCLC Radiogenomics dataset having 211 subjects was used in the study. Ten best models found during experimentation were averaged to form an ensemble. The model ensemble was executed with 10-fold repeated stratified cross-validation, and the results got were tested with metrics like accuracy, recall, precision, F1-score, Cohen's kappa, and ROC-AUC score. The accuracy of the ensemble model showed considerable improvement over the best model found with the single model. The proposed model may help significantly in the automated prognosis of NSCLC and other types of cancers.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        equations & formulas
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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