Volumetric and Functional Activity Lateralization in Healthy Subjects and Patients with Focal Epilepsy: Initial Findings in a 7T MRI Study.
Background and Purpose: In 30% of the patients with focal epilepsy, an epileptogenic lesion cannot be visually detected with structural MRI. Ultra-high field MRI may be able to identify subtle pathology related to the epileptic focus. We set out to assess 7T MRI-derived volumetric and functional act...
| Published in: | Journal of Neuroimaging Vol. 30; no. 5; pp. 666 - 674 |
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| Main Authors: | , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Wiley-Blackwell
Sep/Oct2020
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=146139140&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 146139140 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10512284 L2W jtl: Journal of Neuroimaging issn: 10512284 maglogo: Y pubinfo: dt: Sep/Oct2020 vid: 30 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 146139140 146139140 NLM32472965 146139140 10.1111/jon.12739 NLM32472965 146139140 ppf: 666 ppct: 8 formats: tig: atl: Volumetric and Functional Activity Lateralization in Healthy Subjects and Patients with Focal Epilepsy: Initial Findings in a 7T MRI Study. aug: au: Canjels, Lisanne P.W. Backes, Walter H. Veenendaal, Tamar M. Vlooswijk, Marielle C.G. Hofman, Paul A.M. Aldenkamp, Albert P. Rouhl, Rob P.W. Jansen, Jacobus F.A. van Veenendaal, Tamar M affil: Departments of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, The Netherlands sug: subj: Dominance, Cerebral Physiology Brain Epilepsy, Partial Magnetic Resonance Imaging Methods Epilepsy, Partial Physiopathology Middle Age Female Research Subjects Young Adult Adult Brain Physiopathology Human Hippocampus Physiopathology Hippocampus Male Comparative Studies Multicenter Studies Evaluation Research Validation Studies Clinical Assessment Tools Middle Aged: 45-64 years Adult: 19-44 years Female Male ab: Background and Purpose: In 30% of the patients with focal epilepsy, an epileptogenic lesion cannot be visually detected with structural MRI. Ultra-high field MRI may be able to identify subtle pathology related to the epileptic focus. We set out to assess 7T MRI-derived volumetric and functional activity lateralization of the hippocampus, hippocampal subfields, temporal and frontal lobe in healthy subjects and MRI-negative patients with focal epilepsy.Methods: Twenty controls and 10 patients with MRI-negative temporal or frontal lobe epilepsy (TLE and FLE, respectively) underwent a 7T MRI exam. T1 -weigthed imaging and resting-state fMRI was performed. T1 -weighted images were segmented to yield volumes, while from fMRI data, the fractional amplitude of low frequency fluctuations was calculated. Subsequently, volumetric and functional lateralization was calculated from left-right asymmetry.Results: In controls, volumetric lateralization was symmetric, with a slight asymmetry of the hippocampus and subiculum, while functional lateralization consistently showed symmetry. Contrarily, in epilepsy patients, regions were less symmetric. In TLE patients with known focus, volumetric lateralization in the hippocampus and hippocampal subfields was indicative of smaller ipsilateral volumes. These patients also showed clear functional lateralization, though not consistently ipsilateral or contralateral to the epileptic focus. TLE patients with unknown focus showed an obvious volumetric lateralization, facilitating the localization of the epileptic focus. Lateralization results in the FLE patients were less consistent with the epileptic focus.Conclusion: MRI-derived volume and fluctuation amplitude are highly symmetric in controls, whereas in TLE, volumetric and functional lateralization effects were observed. This highlights the potential of the technique. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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