Quantitative CT-based image registration metrics provide different ventilation and lung motion patterns in prone and supine positions in healthy subjects.
Background: Previous studies suggested that the prone position (PP) improves oxygenation and reduces mortality among patients with acute respiratory distress syndrome (ARDS). However, the mechanism of this clinical benefit of PP is not completely understood. The aim of the present study was to quant...
| Published in: | Respiratory Research Vol. 21; no. 1; pp. 1 - 10 |
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| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
| Published: |
BioMed Central
10/2/2020
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=146196858&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 146196858 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14659921 1D0T jtl: Respiratory Research issn: 14659921 maglogo: N pubinfo: dt: 10/2/2020 vid: 21 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 146196858 146196858 NLM33008396 10.1186/s12931-020-01519-5 NLM33008396 146196858 ppf: 1 ppct: 9 formats: tig: atl: Quantitative CT-based image registration metrics provide different ventilation and lung motion patterns in prone and supine positions in healthy subjects. aug: au: Shin, Kyung Min Choi, Jiwoong Chae, Kum Ju Jin, Gong Yong Eskandari, Ali Hoffman, Eric A. Hall, Chase Castro, Mario Lee, Chang Hyun affil: Department of Radiology, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, South Korea sug: subj: Lung Physiology Supine Position Physiology Prone Position Physiology Lung Tomography, X-Ray Computed Methods Respiratory Airflow Physiology Middle Age Research Subjects Male Aged Adult Respiratory Mechanics Physiology Retrospective Design Female Clinical Assessment Tools Scales Middle Aged: 45-64 years Aged: 65+ years Adult: 19-44 years Male Female ab: Background: Previous studies suggested that the prone position (PP) improves oxygenation and reduces mortality among patients with acute respiratory distress syndrome (ARDS). However, the mechanism of this clinical benefit of PP is not completely understood. The aim of the present study was to quantitatively compare regional characteristics of lung functions in the PP with those in the supine position (SP) using inspiratory and expiratory computed tomography (CT) scans.Methods: Ninety subjects with normal pulmonary function and inspiration and expiration CT images were included in the study. Thirty-four subjects were scanned in PP, and 56 subjects were scanned in SP. Non-rigid image registration-based inspiratory-expiratory image matching assessment was used for regional lung function analysis. Tissue fractions (TF) were computed based on the CT density and compared on a lobar basis. Three registration-derived functional variables, relative regional air volume change (RRAVC), volumetric expansion ratio (J), and three-dimensional relative regional displacement (s*) were used to evaluate regional ventilation and deformation characteristics.Results: J was greater in PP than in SP in the right middle lobe (P = 0 .025), and RRAVC was increased in the upper and right middle lobes (P < 0.001). The ratio of the TF on inspiratory and expiratory scans, J, and RRAVC at the upper lobes to those at the middle and lower lobes and that ratio at the upper and middle lobes to those at the lower lobes of were all near unity in PP, and significantly higher than those in SP (0.98-1.06 vs 0.61-0.94, P < 0.001).Conclusion: We visually and quantitatively observed that PP not only induced more uniform contributions of regional lung ventilation along the ventral-dorsal axis but also minimized the lobar differences of lung functions in comparison with SP. This may help in the clinician's search for an understanding of the benefits of the application of PP to the patients with ARDS or other gravitationally dependent pathologic lung diseases.Trial Registration: Retrospectively registered. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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