Helicobacter Pylori cagA+ Genotype is Associated With Consumption of Untreated Drinking Water in North-Eastern Brazil.
Introduction: This study aimed to identify the Helicobacter pylori cagA+ genotype prevalent in a region of north-eastern Brazil and find possible associations between this genotype and socioeconomic variables. Methods: This cross-sectional study included 751 patients with dyspepsia from a public end...
| Publicado en: | Biological Research for Nursing Vol. 22; no. 4; pp. 544 - 552 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
Oct2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=146204757&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 146204757 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10998004 5WE jtl: Biological Research for Nursing issn: 10998004 maglogo: Y pubinfo: dt: Oct2020 vid: 22 iid: 4 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 146204757 146204757 146266382 146204757 10.1177/1099800420941254 146204757 ppf: 544 ppct: 8 formats: tig: atl: Helicobacter Pylori cagA+ Genotype is Associated With Consumption of Untreated Drinking Water in North-Eastern Brazil. aug: au: Alves de Oliveira Serra, Maria Aparecida Lima, Victor Pereira Santos, Carlos Alberto Andrade Serra dos Moura de Araújo, Márcio Flávio affil: Programa de Pós-Graduação em Saúde e Tecnologia, Centro de Ciências Sociais, Saúde e Tecnologia, 37892Universidade Federal do Maranhão, Imperatriz, Maranhão, Brazil sug: subj: Helicobacter Pylori Transmission Genotype Water Supply Helicobacter Infections Brazil Water Pollution Human Brazil Socioeconomic Factors Cross Sectional Studies Dyspepsia Polymerase Chain Reaction Urease Chi Square Test Odds Ratio Multivariate Analysis Income Confidence Intervals Disease Transmission Prevalence Univariate Statistics Fisher's Exact Test Data Analysis Software Male Female Adult Middle Age Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Introduction: This study aimed to identify the Helicobacter pylori cagA+ genotype prevalent in a region of north-eastern Brazil and find possible associations between this genotype and socioeconomic variables. Methods: This cross-sectional study included 751 patients with dyspepsia from a public endoscopy clinic. Genotyping was carried out on 98 samples from gastric tissue with positive urease test for H. pylori using polymerase chain reaction (PCR). Socioeconomic variables were collected via forms. Pearson's χ2 test was used to analyze associations between variables and odds ratios were obtained to compare effects. Statistical significance was defined as p < 0.05 for univariate and multivariate analyses. Results: H. pylori infection was present in 52.7% of the patients and associated with low income and consumption of untreated drinking water. The prevalence of the cagA+ genotype was 25.5%. Low income was inversely related to the presence of cagA+ genotype, even after adjustment. Untreated drinking water consumption was associated with the presence of the cagA+ genotype in both the univariate (p = 0.03; OR = 2.55; 95% CI: 1.008–6.48) and multivariate (p = 0.03; OR = 2.89; 95% CI: 1.08–7.67) analyses. Conclusion: The findings of this study suggest that water can be an important vehicle for the transmission of pathogenic H. pylori strains and may be a public health challenge, especially in less developed regions with precarious water and sanitary conditions. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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