Digital Whole Slide Imaging Compared With Light Microscopy for Primary Diagnosis in Surgical Pathology: A Multicenter, Double-Blinded, Randomized Study of 2045 Cases.
Context.--The adoption of digital capture of pathology slides as whole slide images (WSI) for educational and research applications has proven utility. Objective.--To compare pathologists' primary diagnoses derived from WSI versus the standard microscope. Because WSIs differ in format and method of...
| Publicado en: | Archives of Pathology & Laboratory Medicine Vol. 144; no. 10; pp. 1245 - 1254 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
College of American Pathologists
Oct2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=146256079&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 146256079 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00039985 1FS jtl: Archives of Pathology & Laboratory Medicine issn: 00039985 maglogo: N pubinfo: dt: Oct2020 vid: 144 iid: 10 pid: 2550 pub: College of American Pathologists place: Northfield, Illinois artinfo: ui: 146256079 146256079 146256079 10.5858/arpa.2019-0569-OA 146256079 ppf: 1245 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Digital Whole Slide Imaging Compared With Light Microscopy for Primary Diagnosis in Surgical Pathology: A Multicenter, Double-Blinded, Randomized Study of 2045 Cases. aug: au: Borowsky, Alexander D. Glassy, Eric F. Wallace, William Dean Kallichanda, Nathash S. Behling, Cynthia A. Miller, Dylan V. Oswal, Hemlata N. Feddersen, Richard M. Bakhtar, Omid R. Mendoza, Arturo E. Molden, Daniel P. Saffer, Helene L. Wixom, Christopher R. Albro, James E. Cessna, Melissa H. Hall, Brian J. Lloyd, Isaac E. Bishop, John W. Darrow, Morgan A. Gui, Dorina affil: Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento sug: subj: Pathology, Clinical Diagnosis, Laboratory Microscopy, Virtual Utilization Microscopy Pathologists Human Randomized Controlled Trials Multicenter Studies Double-Blind Studies Comparative Studies Descriptive Statistics Confidence Intervals Odds Ratio Time Factors ab: Context.--The adoption of digital capture of pathology slides as whole slide images (WSI) for educational and research applications has proven utility. Objective.--To compare pathologists' primary diagnoses derived from WSI versus the standard microscope. Because WSIs differ in format and method of observation compared with the current standard glass slide microscopy, this study is critical to potential clinical adoption of digital pathology. Design.--The study enrolled a total of 2045 cases enriched for more difficult diagnostic categories and represented as 5849 slides were curated and provided for diagnosis by a team of 19 reading pathologists separately as WSI or as glass slides viewed by light microscope. Cases were reviewed by each pathologist in both modalities in randomized order with a minimum 31-day washout between modality reads for each case. Each diagnosis was compared with the original clinical reference diagnosis by an independent central adjudication review. Results.--The overall major discrepancy rates were 3.64% for WSI review and 3.20% for manual slide review diagnosis methods, a difference of 0.44% (95%CI, -0.15 to 1.03). The time to review a case averaged 5.20 minutes for WSI and 4.95 minutes for glass slides. There was no specific subset of diagnostic category that showed higher rates of modality-specific discrepancy, though some categories showed greater discrepancy than others in both modalities. Conclusions.--WSIs are noninferior to traditional glass slides for primary diagnosis in anatomic pathology. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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