Modeling Carbohydrate Counting Error in Type 1 Diabetes Management.
Background: The error in estimating meal carbohydrates (CHO) amount is a critical mistake committed by type 1 diabetes (T1D) subjects. The aim of this study is both to investigate which factors, related to meals and subjects, affect the CHO counting error most and to develop a mathematical model of...
| Publicado en: | Diabetes Technology & Therapeutics Vol. 22; no. 10; pp. 749 - 760 |
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| Autores principales: | , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
Oct2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=146316762&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 146316762 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15209156 N3C jtl: Diabetes Technology & Therapeutics issn: 15209156 maglogo: N pubinfo: dt: Oct2020 vid: 22 iid: 10 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 146316762 146316762 NLM32223551 146316762 10.1089/dia.2019.0502 NLM32223551 146316762 ppf: 749 ppct: 11 formats: tig: atl: Modeling Carbohydrate Counting Error in Type 1 Diabetes Management. aug: au: Roversi, Chiara Vettoretti, Martina Del Favero, Simone Facchinetti, Andrea Sparacino, Giovanni affil: Department of Information Engineering, University of Padova, Padova, Italy. sug: subj: Diabetes Mellitus, Type 1 Diet Therapy Dietary Carbohydrates Analysis Models, Theoretical Diabetes Mellitus, Type 1 Drug Therapy Human Adult Blood Glucose Insulin Meals Comparative Studies Multicenter Studies Evaluation Research Validation Studies Adult: 19-44 years ab: Background: The error in estimating meal carbohydrates (CHO) amount is a critical mistake committed by type 1 diabetes (T1D) subjects. The aim of this study is both to investigate which factors, related to meals and subjects, affect the CHO counting error most and to develop a mathematical model of CHO counting error embeddable in T1D patient decision simulators to conduct in silico clinical trials. Methods: A published dataset of 50 T1D adults is used, which includes a patient's CHO count of 692 meals, dietitian's estimates of meal composition (used as reference), and several potential explanatory factors. The CHO counting error is modeled by multiple linear regression, with stepwise variable selection starting from 10 candidate predictors, that is, education level, insulin treatment duration, age, body weight, meal type, CHO, lipid, energy, protein, and fiber content. Inclusion of quadratic and interaction terms is also evaluated. Results: Larger errors correspond to larger meals, and most of the large meals are underestimated. The linear model selects CHO (P < 0.00001), meal type (P < 0.00001), and body weight (P = 0.047), whereas its extended version embeds a quadratic term of CHO (P < 0.00001) and interaction terms of meal type with CHO (P = 0.0001) and fiber amount (P = 0.001). The extended model explains 34.9% of the CHO counting error variance. Comparison with the CHO counting error description previously used in the T1D patient decision simulator shows that the proposed models return more credible realizations. Conclusions: The most important predictors of CHO counting errors are CHO and meal type. The mathematical models proposed improve the description of patients' behavior in the T1D patient decision simulator. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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