Mortality and HRQoL in ICU patients with delirium: Protocol for 1-year follow-up of AID-ICU trial.
Background: Intensive care unit (ICU)-acquired delirium is frequent and associated with poor short- and long-term outcomes for patients in ICUs. It therefore constitutes a major healthcare problem. Despite limited evidence, haloperidol is the most frequently used pharmacological intervention against...
| Publicado en: | Acta Anaesthesiologica Scandinavica Vol. 64; no. 10; pp. 1519 - 1526 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | protocol tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Nov2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=146362424&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 146362424 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00015172 44A jtl: Acta Anaesthesiologica Scandinavica issn: 00015172 maglogo: Y pubinfo: dt: Nov2020 vid: 64 iid: 10 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 146362424 146362424 NLM33460045 146362424 10.1111/aas.13679 NLM33460045 146362424 ppf: 1519 ppct: 7 formats: tig: atl: Mortality and HRQoL in ICU patients with delirium: Protocol for 1-year follow-up of AID-ICU trial. aug: au: Mortensen, Camilla B. Poulsen, Lone M. Andersen‐Ranberg, Nina C. Perner, Anders Lange, Theis Estrup S, Stine Ebdrup, Bjørn H. Egerod, Ingrid Rasmussen, Bodil S. Hästbacka, Johanna Caballero, Jesús Citerio, Giuseppe Morgan, Matthew P.G. Samuelson, Karin Mathiesen, Ole Andersen-Ranberg, Nina C affil: Department of Anaesthesiology and Intensive Care Medicine, Centre for Anaesthesiological Research, Zealand University Hospital, Koege, Denmark sug: subj: Quality of Life Delirium Drug Therapy Human Intensive Care Units Prospective Studies Critical Care Comparative Studies Multicenter Studies Evaluation Research Validation Studies Clinical Trials Funding Source ab: Background: Intensive care unit (ICU)-acquired delirium is frequent and associated with poor short- and long-term outcomes for patients in ICUs. It therefore constitutes a major healthcare problem. Despite limited evidence, haloperidol is the most frequently used pharmacological intervention against ICU-acquired delirium. Agents intervening against Delirium in the ICU (AID-ICU) is an international, multicentre, randomised, blinded, placebo-controlled trial investigates benefits and harms of treatment with haloperidol in patients with ICU-acquired delirium. The current pre-planned one-year follow-up study of the AID-ICU trial population aims to explore the effects of haloperidol on one-year mortality and health related quality of life (HRQoL).Methods: The AID-ICU trial will include 1000 participants. One-year mortality will be obtained from the trial sites; we will validate the vital status of Danish participants using the Danish National Health Data Registers. Mortality will be analysed by Cox-regression and visualized by Kaplan-Meier curves tested for significance using the log-rank test. We will obtain HRQoL data using the EQ-5D instrument. HRQoL analysis will be performed using a general linear model adjusted for stratification variables. Deceased participants will be designated the worst possible value.Results: We expect to publish results of this study in 2022.Conclusion: We expect that this one-year follow-up study of participants with ICU-acquired delirium allocated to haloperidol vs. placebo will provide important information on the long-term consequences of delirium including the effects of haloperidol. We expect that our results will improve the care of this vulnerable patient group. pubtype: Academic Journal doctype: protocol tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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