BOLD responses to inhibition in cannabis-using adolescents and emerging adults after 2 weeks of monitored cannabis abstinence.
Rationale: Previous studies have suggested that chronic cannabis use has been associated with increased blood oxygen level–dependent (BOLD) response during a response inhibition task; however, these studies primarily included males. Objectives: We investigated whether gender moderated the effects of...
| Publicado en: | Psychopharmacology Vol. 237; no. 11; pp. 3259 - 3269 |
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| Autores principales: | , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Nov2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=146477642&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 146477642 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Nov2020 vid: 237 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 146477642 144761884 10.1007/s00213-020-05608-7 146477642 ppf: 3259 ppct: 10 formats: fmt: @attributes: type: P tig: atl: BOLD responses to inhibition in cannabis-using adolescents and emerging adults after 2 weeks of monitored cannabis abstinence. aug: au: Wallace, Alexander L. Maple, Kristin E. Barr, Alicia T. Lisdahl, Krista M. affil: Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI, USA sug: ab: Rationale: Previous studies have suggested that chronic cannabis use has been associated with increased blood oxygen level–dependent (BOLD) response during a response inhibition task; however, these studies primarily included males. Objectives: We investigated whether gender moderated the effects of cannabis use on BOLD response and behavioral performance during a Go-NoGo task in adolescents and young adults following 2 weeks of monitored abstinence. Methods: Participants included 77 16–26-year olds (MJ = 36, controls = 41). An emotion-based Go-NoGo task required participants to inhibit their response during a calm face. A whole-brain analysis looked at differences between cannabis group, gender, and their interaction. Results: Significant greater BOLD responses were observed in cannabis users compared with that in controls in the left frontal cortex, left cingulate cortex, and the left thalamus during correct response inhibitions; gender did not moderate these effects. Conclusion: Supporting previous research, cannabis users showed greater BOLD responses in core areas associated with response inhibition during a Go-NoGo task, even after a minimum of 2 weeks of abstinence. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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